Entry Detail



General Information

Database ID:LDA0001111
Species:Homo sapiens
Confidence Score:0.5483
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:LHX1-DT
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):36861674End Site(bp):36936661
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000277268
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
LHX1
17
36936785
36944612
+
AATF
17
36948875
37056871
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR2909
17
37033745
37033813
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3069D001254
Disease Name:astrocytomaAstrocytoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms
Define:A malignant glioma that is has_material_basis_in astocyte cells, a type of star-shaped glial cell, located_in the cerebrum.Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
Alias:Astrocytic tumor//astrocytoma of brain (disorder)//astrocytoma of Cerebrum//astrocytoma, no ICD-O subtype (morphologic abnormality)//astroglioma//cerebral astrocytomaAstrocytomas//Astroglioma//Astrogliomas//Glioma, Astrocytic//Astrocytic Glioma//Astrocytic Gliomas//Gliomas, Astrocytic//Astrocytoma, Grade I//Astrocytomas, Grade I//Grade I Astrocytoma//Grade I Astrocytomas//Astrocytoma, Grade II//Astrocytomas, Grade II//Grade II Astrocytoma//Grade II Astrocytomas//Astrocytoma, Protoplasmic//Astrocytomas, Protoplasmic//Protoplasmic Astrocytoma//Protoplasmic Astrocytomas//Astrocytoma, Subependymal Giant Cell//Subependymal Giant Cell Astrocytoma//Pilocytic Astrocytoma//Astrocytoma, Pilocytic//Astrocytomas, Pilocytic//Pilocytic Astrocytomas//Childhood Cerebral Astrocytoma//Astrocytoma, Childhood Cerebral//Astrocytomas, Childhood Cerebral//Cerebral Astrocytoma, Childhood//Cerebral Astrocytomas, Childhood//Childhood Cerebral Astrocytomas//Fibrillary Astrocytoma//Astrocytoma, Fibrillary//Astrocytomas, Fibrillary//Fibrillary Astrocytomas//Gemistocytic Astrocytoma//Astrocytoma, Gemistocytic//Astrocytomas, Gemistocytic//Gemistocytic Astrocytomas//Intracranial Astrocytoma//Astrocytoma, Intracranial//Astrocytomas, Intracranial//Intracranial Astrocytomas//Juvenile Pilocytic Astrocytoma//Astrocytoma, Juvenile Pilocytic//Astrocytomas, Juvenile Pilocytic//Juvenile Pilocytic Astrocytomas//Pilocytic Astrocytoma, Juvenile//Pilocytic Astrocytomas, Juvenile//Oligoastrocytoma, Mixed//Mixed Oligoastrocytoma//Mixed Oligoastrocytomas//Oligoastrocytomas, Mixed//Anaplastic Astrocytoma//Anaplastic Astrocytomas//Astrocytoma, Anaplastic//Astrocytomas, Anaplastic//Astrocytoma, Grade III//Astrocytomas, Grade III//Grade III Astrocytoma//Grade III Astrocytomas//Cerebral Astrocytoma//Astrocytoma, Cerebral//Astrocytomas, Cerebral//Cerebral Astrocytomas

 

Evidence Support

Strong Evidence:N/A
Weak Evidence:Microarray
Prediction Method:N/A

 

Reference

[1] PubMed ID:26252651
Disease Name:astrocytoma
Sample:brain
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:Microarray
Description:Among the lncRNAs detected,3806 lncRNAs with a fold change>2 or <0.5 and a q value<0.05 were found to have significantly different expression levels in astrocytoma samples compared to NAT samples. Of those,1196 were downregulated and 2610 were upregulated.
Author:Zhi F,Wang Q,Xue L,Shao N,Wang R,Deng D,Wang S,Xia X,Yang Y
Year:2015
Title:The Use of Three Long Non-Coding RNAs as Potential Prognostic Indicators of Astrocytoma.
Causality:No