Entry Detail



General Information

Database ID:LDA0003605
Species:Homo sapiens
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:TP73-AS1
Full Name:TP73 antisense RNA 1
Category:lncRNA
Species:Homo sapiens
Synonyms:PDAM
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):3735601End Site(bp):3747336
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000227372
HGNC ID:HGNC:29052
Entrez Gene:57212
VEGA ID:OTTHUMG00000003414
UCSC ID:uc009vlm.4
ENA:N/A
RefSeq Accession:NR_033708
UniProtKB:Q9UF72

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
WRAP73
1
3630767
3652761
-
TP73
1
3652520
3736201
+
CCDC27
1
3746460
3771645
+
SMIM1
1
3772761
3775982
+
LRRC47
1
3778558
3796504
-
CEP104
1
3812081
3857214
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Skin and Connective Tissue Diseases
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerTumors, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Neoplasms, Breast//Breast Neoplasm//Neoplasm, Breast//Breast Cancer//Cancer, Breast//Cancer of the Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human

 

Evidence Support

Strong Evidence:Knockdown//Luciferase reporter gene assay//qRT-PCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:28639399
Disease Name:breast cancer
Sample:BC cell lines and clinical tumor samples
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR//Knockdown//Luciferase reporter gene assay
Description:In the present study, TP73-AS1 was specifically upregulated in BC tissues and BC cell lines and was correlated to a poorer prognosis in patients with BC.
Author:Yao J,Xu F,Zhang D,Yi W,Chen X,Chen G,Zhou E
Year:2018
Title:TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition.
Causality:Yes