Entry Detail



General Information

Database ID:LDA0003627
Species:Homo sapiens
Confidence Score:0.7311
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:BLACAT1
Full Name:bladder cancer associated transcript 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:linc-UBC1//LINC00912//onco-lncRNA-30
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):205434886End Site(bp):205437879
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000281406
HGNC ID:HGNC:48597
Entrez Gene:101669762
VEGA ID:OTTHUMG00000189561
UCSC ID:N/A
ENA:BX640973
RefSeq Accession:NR_103783
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KLHDC8A
1
205336065
205357090
-
LEMD1
1
205381378
205457091
-
CDK18
1
205504595
205532793
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR135B
1
205448302
205448398
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:162D009369
Disease Name:cancerNeoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms
Define:A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Alias:malignant neoplasm//malignant tumor //primary cancerNeoplasia//Neoplasias//Neoplasm//Tumors//Tumor//Benign Neoplasms//Neoplasms, Benign//Benign Neoplasm//Neoplasm, Benign//Malignancy//Malignancies//Cancer//Cancers

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:29037201
Disease Name:cancer
Sample:serum and tissues
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR
Description:Our results showed that the change of serum BLACAT1 expression was similar to those in matched tissues. The expression level of BLACAT1 both in serum and tissues in multiple cancer types were significantly upregulated compared to those of matched non-cancer participants. The serum BLACAT1 had a high diagnostic performance among these 12 types of cancer. The relative AUC of serum BLACAT1 in cancer patients ranged from 0.833 to 0.967 compared to that in healthy subjects. Surprisingly, Kaplan-Meier survival analysis revealed that the high expression level of BLACAT1 was significantly associated with poor overall survival only in uterine corpus endometrial carcinoma (p_=_0.002, log-rank test).
Author:Chen X,Dai M,Zhu H,Li J,Huang Z,Liu X,Huang Y,Chen J,Dai S
Year:2017
Title:Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer.
Causality:No