Entry Detail



General Information

Database ID:LDA0003742
Species:Homo sapiens
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:PRO1073//MALAT-1//NCRNA00047//HCN//NEAT2//LINC00047//mascRNA
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497762End Site(bp):65506516
Gene Summary:This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
External Links:
Ensembl ID:ENSG00000251562
HGNC ID:HGNC:29665
Entrez Gene:378938
VEGA ID:OTTHUMG00000166322
UCSC ID:uc010roh.5
ENA:AF001540
RefSeq Accession:NR_002819
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
FRMD8
11
65386599
65413525
+
SCYL1
11
65525077
65538704
+
LTBP3
11
65538805
65558930
-
SSSCA1
11
65570430
65573942
+
FAM89B
11
65572349
65574198
+
EHBP1L1
11
65576038
65592650
+
KCNK7
11
65592855
65595996
-
MAP3K11
11
65597755
65615382
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR612
11
65444458
65444557
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4947D018281
Disease Name:cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms
Define:A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:adult primary Cholangiocarcinoma//adult primary cholangiocellular carcinoma//cholangiosarcomaCholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Evidence Support

Strong Evidence:qPCR//qRT-PCR//Transwell assay
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:28592124
Disease Name:cholangiocarcinoma
Sample:cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR//Transwell assay
Description:And we discovered that MALAT1 was up-regulated in cholangiocarcinoma cancer cells.
Author:Wang C,Mao ZP,Wang L,Wu GH,Zhang FH,Wang DY,Shi JL
Year:2017
Title:Long non-coding RNA MALAT1 promotes cholangiocarcinoma cell proliferation and invasion by activating PI3K/Akt pathway.
Causality:Yes

[2] PubMed ID:28592124
Disease Name:cholangiocarcinoma
Sample:N/A
Dysfunction Pattern:Interaction [PI3K/Akt pathway]
Validated Method:qPCR
Description:In addition, MALAT1 may activate PI3K/Akt pathway.
Author:Wang C,Mao ZP,Wang L,Wu GH,Zhang FH,Wang DY,Shi JL
Year:2017
Title:Long non-coding RNA MALAT1 promotes cholangiocarcinoma cell proliferation and invasion by activating PI3K/Akt pathway.
Causality:Yes