Entry Detail



General Information

Database ID:LDA0004170
Species:Homo sapiens
Confidence Score:0.9462
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:NKILA
Full Name:NF-kappaB interacting lncRNA
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):57710183End Site(bp):57712780
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000278709
HGNC ID:HGNC:51599
Entrez Gene:105416157
VEGA ID:OTTHUMG00000186958
UCSC ID:N/A
ENA:AK056098
RefSeq Accession:NR_131157
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZBP1
20
57603846
57620576
-
PMEPA1
20
57648392
57711536
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3748C562729
Disease Name:esophagus squamous cell carcinomaEsophageal Squamous Cell Carcinoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationSupplementary Concept
Define:An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.A carcinoma that originates from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large POLYPLOID lesions. Somatic mutations have been identified in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes.
Alias:SCC of esophagus//squamous cell carcinoma of esophagus (disorder)N/A

 

Evidence Support

Strong Evidence:Gain- and Loss-of-function assays//RT-PCR
Weak Evidence:RNA sequencing
Prediction Method:N/A

 

Reference

[1] PubMed ID:29379981
Disease Name:esophageal squamous cell carcinoma
Sample:ESCC tumor tissues
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:RT-PCR//Gain- and Loss-of-function assays//RNA sequencing
Description:In this study, we performed RNA-seq to compare lncRNAs expression levels between TGF-β1-treated and untreated ESCC cells and observed that NF-kappaB-interacting lncRNA (NKILA) was remarkably upregulated by the classical TGF-β signaling pathway. RNA profiling of 39 pairs ESCC tumor and adjacent nontumor samples using RT-qPCR demonstrated that NKILA is significantly downregulated in ESCC tumor tissues, and NKILA expression levels were significantly decreased in advanced tumor tissues (III and IV) compared to early stages (I and II) (p_<_0.01). Gain- and loss-of-function assays showed that NKILA inhibited ESCC cell metastasis in vitro and in vivo, and mechanism studies showed that NKILA repressed MMP14 expression by inhibiting IκBα phosphorylation and NF-κB activation. Collectively, these findings suggest that the TGF-β-induced lncRNA NKILA has potential as an antimetastasis therapy.
Author:Lu Z,Chen Z,Li Y,Wang J,Zhang Z,Che Y,Huang J,Sun S,Mao S,Lei Y,Gao Y,He J
Year:2018
Title:TGF-β-induced NKILA inhibits ESCC cell migration and invasion through NF-κB/MMP14 signaling.
Causality:Yes