Entry Detail



General Information

Database ID:LDA0004174
Species:Homo sapiens
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:NCRNA00079//LINC00079//onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
Gene Summary:This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]
External Links:
Ensembl ID:ENSG00000249859
HGNC ID:HGNC:9709
Entrez Gene:5820
VEGA ID:OTTHUMG00000164871
UCSC ID:uc003ysl.4
ENA:M31519
RefSeq Accession:NR_003367
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MYC
8
127735434
127741434
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR1204
8
127795962
127796028
+
MIR1205
8
127960633
127960695
+
MIR1206
8
128008898
128008956
+
MIR1207
8
128049152
128049238
+
MIR1208
8
128150116
128150188
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3748C562729
Disease Name:esophagus squamous cell carcinomaEsophageal Squamous Cell Carcinoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationSupplementary Concept
Define:An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.A carcinoma that originates from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large POLYPLOID lesions. Somatic mutations have been identified in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes.
Alias:SCC of esophagus//squamous cell carcinoma of esophagus (disorder)N/A

 

Evidence Support

Strong Evidence:qPCR//RT-PCR//Western blot
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:28404954
Disease Name:esophageal squamous cell carcinoma
Sample:ESCC tissue, cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:RT-PCR//Western blot
Description:Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth_in vitro_and_in vivo.
Author:Li PD,Hu JL,Ma C,Ma H,Yao J,Chen LL,Chen J,Cheng TT,Yang KY,Wu G,Zhang WJ,Cao RB
Year:2017
Title:Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1.
Causality:Yes

[2] PubMed ID:28404954
Disease Name:esophageal squamous cell carcinoma
Sample:N/A
Dysfunction Pattern:Interaction [miR-203]
Validated Method:qPCR
Description:Our results suggest that PVT1 promote ESCC progression via functioning as a molecular sponge for miR-203 and LASP1 and provide the first evidence of dysregulated PVT1/miR-203/LASP1 axis in ESCC.
Author:Li PD,Hu JL,Ma C,Ma H,Yao J,Chen LL,Chen J,Cheng TT,Yang KY,Wu G,Zhang WJ,Cao RB
Year:2017
Title:Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1.
Causality:Yes