Entry Detail



General Information

Database ID:LDA0004248
Species:Homo sapiens
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:lncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27107777End Site(bp):27134302
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000253552
HGNC ID:HGNC:43745
Entrez Gene:285943
VEGA ID:OTTHUMG00000063274
UCSC ID:uc064cfs.1
ENA:BC035889
RefSeq Accession:NR_122069
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HOXA1
7
27092993
27095996
-
HOXA2
7
27100354
27102811
-
HOXA3
7
27106184
27152581
-
HOXA4
7
27128507
27130799
-
HOXA5
7
27141052
27143668
-
HOXA6
7
27145396
27150603
-
HOXA7
7
27153716
27157936
-
HOXA9
7
27162435
27175180
-
AC004080.3
7
27163535
27180013
-
HOXA10
7
27170591
27180261
-
HOXA11
7
27181510
27185223
-
HOXA13
7
27193503
27200106
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR196B
7
27169480
27169563
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4948N/A
Disease Name:gallbladder carcinomaN/A
Category:Disease OntologyN/A
Type:disease of cellular proliferationN/A
Define:A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.N/A
Alias:cancer of the gallbladder//carcinoma gallbladder//carcinoma gallbladder//carcinoma gallbladder//carcinoma of gallbladder (disorder)N/A

 

Evidence Support

Strong Evidence:qPCR//qRT-PCR//Transwell assay
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:28388535
Disease Name:gallbladder carcinoma
Sample:gallbladder tissue, cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR//Transwell assay
Description:Here, we reported that HOXA cluster antisense RNA2 (HOXA-AS2) was upregulated in GBC.
Author:Zhang P,Cao P,Zhu X,Pan M,Zhong K,He R,Li Y,Jiao X,Gao Y
Year:2017
Title:Upregulation of long non-coding RNA HOXA-AS2 promotes proliferation and induces epithelial-mesenchymal transition in gallbladder carcinoma.
Causality:Yes

[2] PubMed ID:28388535
Disease Name:gallbladder carcinoma
Sample:N/A
Dysfunction Pattern:Interaction [EMT]
Validated Method:qPCR
Description:Further functional assays indicated that HOXA-AS2 overexpression significantly promoted GBC cell migration and invasion by promoting EMT._
Author:Zhang P,Cao P,Zhu X,Pan M,Zhong K,He R,Li Y,Jiao X,Gao Y
Year:2017
Title:Upregulation of long non-coding RNA HOXA-AS2 promotes proliferation and induces epithelial-mesenchymal transition in gallbladder carcinoma.
Causality:Yes