Entry Detail



General Information

Database ID:LDA0004388
Species:Homo sapiens
Confidence Score:0.982
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:PTCSC3
Full Name:papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):36136108End Site(bp):36176468
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000259104
HGNC ID:HGNC:43959
Entrez Gene:100886964
VEGA ID:OTTHUMG00000170617
UCSC ID:uc031qoh.3
ENA:JN689234//CB987890
RefSeq Accession:NR_049735
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3070D005910
Disease Name:malignant gliomaGlioma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms
Define:A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:glial cell tumor//glioma//glioma (morphologic abnormality)//glioma NOS//glioma NOS (morphologic abnormality)//glioma, malignant//glioma, malignant, no ICD-O subtype//glioma, NOS//Gliomas (morphologic abnormality)//malignant glioma (morphologic abnormality)//malignant glioma - category//malignant Neuroglial tumor//Neuroglial tumorGliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Evidence Support

Strong Evidence:qPCR//qRT-PCR//Transwell assay//Western blot
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:28187755
Disease Name:Glioma
Sample:microglia, cell lines
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:qRT-PCR//Transwell assay//Western blot
Description:LncRNA PTCSC3 was significantly downregulated in glioma cell lines. The overexpression of lncRNA PTCSC3 suppressed proliferation and induced apoptosis in U87 and U251 cells. Additionally, the overexpression of lncRNA PTCSC3 inhibited the migration and invasion of U87 and U251 cells. Moreover, lncRNA PTCSC3 inhibited the epithelial-mesenchymal transition of U87 cells._
Author:Xia S,Ji R,Zhan W
Year:2017
Title:Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway.
Causality:Yes

[2] PubMed ID:28187755
Disease Name:Glioma
Sample:N/A
Dysfunction Pattern:Interaction [Wnt/β-catenin]
Validated Method:qPCR
Description:The study also demonstrated that LRP6, as a receptor of the Wnt/β-catenin pathway, was a target of lncRNA PTCSC3. By evaluating the expression levels of Axin1, active β-catenin, c-myc, and cyclin D1, the study indicated that lncRNA PTCSC3 inhibited the activation of the Wnt/β-cateninpathway through targeting LRP6.
Author:Xia S,Ji R,Zhan W
Year:2017
Title:Long noncoding RNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) inhibits proliferation and invasion of glioma cells by suppressing the Wnt/β-catenin signaling pathway.
Causality:Yes