Entry Detail



General Information

Database ID:LDA0005910
Species:Homo sapiens
Confidence Score:0.7311
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:lncRNA-ATB
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
Gene Summary:N/A
External Links:
Ensembl ID:N/A
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases//Endocrine System Diseases
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorNeoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:26482611
Disease Name:pancreatic cancer
Sample:tissue, cell line (HPDE6c-7)
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:qPCR
Description:We found that lncRNA-ATB expression was decreased in pancreatic cancer tissues and pancreatic cancer cell lines. Low lncRNA-ATB expression levels were significantly correlated with lymph node metastases (yes vs. no,P = 0.009),neural invasion (positive vs. negative,P = 0.049),and clinical stage (early stage vs. advanced stage,P = 0.014). Moreover,patients with low lncRNA-ATB expression levels exhibited markedly worse overall survival prognoses (P < 0.001). Multivariate analysis indicated that decreased lncRNA-ATB expression was an independent predictor of poor prognosis in pancreatic cancer patients (P = 0.005).
Author:Qu S,Yang X,Song W,Sun W,Li X,Wang J,Zhong Y,Shang R,Ruan B,Zhang Z,Zhang X,Li H
Year:2016
Title:Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer.
Causality:No