Entry Detail



General Information

Database ID:LDA0005941
Species:Homo sapiens
Confidence Score:0.9462
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:MEG3
Full Name:maternally expressed 3 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:GTL2//NCRNA00023//LINC00023//onco-lncRNA-83
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100779410End Site(bp):100861031
Gene Summary:This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
External Links:
Ensembl ID:ENSG00000214548
HGNC ID:HGNC:14575
Entrez Gene:55384
VEGA ID:OTTHUMG00000029052
UCSC ID:uc059fga.1
ENA:AB032607
RefSeq Accession:NR_002766
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DLK1
14
100725705
100738224
+
RTL1
14
100880655
100884847
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR2392
14
100814491
100814574
+
MIR770
14
100852390
100852487
+
MIR493
14
100869060
100869148
+
MIR337
14
100874493
100874585
+
MIR665
14
100875033
100875104
+
MIR431
14
100881007
100881120
+
MIR433
14
100881886
100881978
+
MIR127
14
100882979
100883075
+
MIR432
14
100884483
100884576
+
MIR136
14
100884702
100884783
+
MIR370
14
100911139
100911213
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1798N/A
Disease Name:pancreatic endocrine carcinomaN/A
Category:Disease OntologyN/A
Type:disease of cellular proliferationN/A
Define:An islet cell tumor that has_material_basis_in epithelial cells.N/A
Alias:carcinoma of endocrine pancreas (disorder)//Islet cell carcinoma (morphologic abnormality)//malignant neoplasm of islets of Langerhans//pancreatic neuroendocrine carcinomaN/A

 

Evidence Support

Strong Evidence:Luciferase reporter gene assay//qPCR
Weak Evidence:Microarray
Prediction Method:N/A

 

Reference

[1] PubMed ID:25565142
Disease Name:pancreatic endocrine carcinoma
Sample:tissue, cell line (MIN6, MIN6-4N)
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:Luciferase reporter gene assay//qPCR//Microarray
Description:We found that Meg3 has tumor-suppressor activity in PNET cells because the overexpression of Meg3 in MIN6 cells (insulin-secreting mouse PNET cell line) blocked cell proliferation and delayed cell cycle progression. Gene expression microarray analysis showed that Meg3 overexpression in MIN6 mouse insulinoma cells down-regulated the expression of the protooncogene c-Met (hepatocyte growth factor receptor),and these cells showed significantly reduced cell migration/invasion. Compared with normal islets,mouse or human MEN1-associated PNETs expressed less MEG3 and more c-MET
Author:Modali SD,Parekh VI,Kebebew E,Agarwal SK
Year:2015
Title:Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors.
Causality:No