Entry Detail



General Information

Database ID:LDA0006616
Species:Homo sapiens
Confidence Score:0.6606
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:RP11-68I3.11
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
Gene Summary:N/A
External Links:
Ensembl ID:N/A
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:D054058N/A
Disease Name:Acute Coronary SyndromeN/A
Category:MeSHN/A
Type:Cardiovascular DiseasesN/A
Define:An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.N/A
Alias:Acute Coronary Syndromes//Coronary Syndrome, Acute//Coronary Syndromes, Acute//Syndrome, Acute Coronary//Syndromes, Acute CoronaryN/A

 

Evidence Support

Strong Evidence:N/A
Weak Evidence:ROC//Univariate and Multivariate Cox regression analyses
Prediction Method:N/A

 

Reference

[1] PubMed ID:29434722
Disease Name:Acute Coronary Syndrome
Sample:N/A
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:Univariate and Multivariate Cox regression analyses//ROC
Description:Out of the 2,332 lncRNAs assessed, it was identified that 18 lncRNAs were upregulated and 35 lncRNAs were downregulated in patients with MI compared to those with UA. Furthermore, the expression profiles of patients with ACS were compared at different time points and significantly altered lncRNA expression was observed during the progression of ACS. A total of 7 candidate lncRNA biomarkers were identified and an lncRNA-based classifier was developed to predict MI risk based on the expression data of the 7 lncRNAs using random forest and support vector machine strategies. This achieved a classification accuracy of 90.38% with a sensitivity of 100% and a specificity of 68.75%. Additionally, functional analysis suggested that these 7 lncRNAs may be involved in known MI-associated biological processes and pathways.
Author:Lu Y,Meng X,Wang L,Wang X
Year:2018
Title:Analysis of long non-coding RNA expression profiles identifies functional lncRNAs associated with the progression of acute coronary syndromes.
Causality:No