Entry Detail



General Information

Database ID:LDA0006619
Species:Homo sapiens
Confidence Score:0.8785
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:BALR-2
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
Gene Summary:N/A
External Links:
Ensembl ID:N/A
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9952D054198
Disease Name:acute lymphocytic leukemiaPrecursor Cell Lymphoblastic Leukemia-Lymphoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Hemic and Lymphatic Diseases//Immune System Diseases
Define:A lymphoblastic leukemia that is characterized by over production of lymphoblasts.A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
Alias:acute lymphoblastic leukemiaPrecursor Cell Lymphoblastic Leukemia Lymphoma//Leukemia, Acute Lymphoblastic//Acute Lymphoblastic Leukemia//Leukemia, Lymphoblastic//Leukemia, Lymphoblastic, Acute//Leukemia, Lymphocytic, Acute//Lymphoblastic Leukemia//Lymphoblastic Leukemia, Acute//Lymphoblastic Lymphoma//Lymphocytic Leukemia, Acute//Acute Lymphocytic Leukemia//Leukemia, Acute Lymphocytic//Lymphoma, Lymphoblastic//Acute Lymphoid Leukemia//Leukemia, Acute Lymphoid//Lymphoid Leukemia, Acute//Leukemia, Lymphoid, Acute//Leukemia, Lymphocytic, Acute, L1//Lymphocytic Leukemia, L1//L1 Lymphocytic Leukemia//Leukemia, L1 Lymphocytic//Lymphoblastic Leukemia, Acute, Childhood//Lymphoblastic Leukemia, Acute, L1//ALL, Childhood//Childhood ALL//Leukemia, Lymphoblastic, Acute, L1//Leukemia, Lymphocytic, Acute, L2//Lymphocytic Leukemia, L2//L2 Lymphocytic Leukemia//Leukemia, L2 Lymphocytic//Lymphoblastic Leukemia, Acute, Adult//Lymphoblastic Leukemia, Acute, L2//Leukemia, Lymphoblastic, Acute, L2//Leukemia, Lymphoblastic, Acute, Philadelphia-Positive

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:Microarray
Prediction Method:N/A

 

Reference

[1] PubMed ID:25681502
Disease Name:acute lymphocytic leukemia
Sample:blood
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//Microarray
Description:Importantly,high expression of BALR-2 correlated with poor overall survival and diminished response to prednisone treatment. BALR-2 plays a functional role in the pathogenesis and/or clinical responsiveness of B-ALL and that altering the levels of particular lncRNAs may provide a future diretcion for therapeutic development.
Author:Fernando TR,Rodriguez-Malave NI,Waters EV,Yan W,Casero D,Basso G,Pigazzi M,Rao DS
Year:2015
Title:LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia.
Causality:Yes