Entry Detail



General Information

Database ID:LDA0006788
Species:Mus musculus
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:Malat1
Full Name:metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
Category:lncRNA
Species:Mus musculus
Synonyms:2210401K01Rik//9430072K23Rik//NEAT2
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):5795690End Site(bp):5802672
Gene Summary:N/A
External Links:
Ensembl ID:ENSMUSG00000092341
HGNC ID:N/A
Entrez Gene:72289
VEGA ID:OTTMUSG00000037798
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:B0LAE7

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
Map3k11
19
5689131
5702862
+
Kcnk7
19
5704367
5707101
+
Ehbp1l1
19
5707376
5726317
-
Fam89b
19
5728087
5729653
-
Sssca1
19
5728088
5731732
-
Ltbp3
19
5740904
5758532
+
Scyl1
19
5758427
5771401
-
Frmd8
19
5849702
5875274
-
Slc25a45
19
5877808
5885766
+
Tigd3
19
5891139
5894107
-
Dpf2
19
5896516
5913010
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:qPCR//qRT-PCR//Western blot
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:16878148
Disease Name:hepatocellular carcinoma
Sample:neoplastic cell
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR
Description:The gene appears to be the murine ortholog of the human alpha gene,that is,MALAT-1. The gene and homologs lack credible open reading frames,consistent with a highly conserved large noncoding RNA (ncRNA). In all nodules of procarcinogen-induced murine hepatocellular carcinomas (HCCs) and human HCCs,expression was markedly elevated compared to the uninvolved liver.Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver,advancing this as a molecule of interest. This ncRNA was overexpressed in all five non-hepatic human carcinomas analysed,consistent with a potential marker for neoplastic cells and potential participant in the molecular cell biology of neoplasia.
Author:Lin R,Maeda S,Liu C,Karin M,Edgington TS
Year:2007
Title:A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas.
Causality:No

[2] PubMed ID:28469957
Disease Name:hepatocellular carcinoma
Sample:HCC tissue;cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR//Western blot
Description:Firstly, we found that expression of MALAT1 was strongly up-regulated in HCC tissues and was directly proportional to the expression of HBx. Moreover, in HBx transfected LO2 and HepG2 cells, MALAT1 was also up-regulated compared with non-transfected cells. Then, we observed up-regulated MALAT1 in HepG2 cells could promote cell invasion and migration, whereas knockdown of MALAT1 in HBx-expressing hepatic cells (HepG2-HBx) resulted in a markedly inhibition of cell invasion and migration both_in vitro_and_in vivo._
Author:Hou Z,Xu X,Fu X,Tao S,Zhou J,Liu S,Tan D
Year:2017
Title:HBx-related long non-coding RNA MALAT1 promotes cell metastasis via up-regulating LTBP3 in hepatocellular carcinoma.
Causality:Yes