Entry Detail



General Information

Database ID:LDA0006807
Species:Mus musculus
Confidence Score:0.8808
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:Neat1
Full Name:nuclear paraspeckle assembly transcript 1 (non-protein coding)
Category:lncRNA
Species:Mus musculus
Synonyms:2310043N10Rik
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):5824708End Site(bp):5845478
Gene Summary:N/A
External Links:
Ensembl ID:ENSMUSG00000092274
HGNC ID:N/A
Entrez Gene:66961
VEGA ID:OTTMUSG00000037797
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
Ehbp1l1
19
5707376
5726317
-
Fam89b
19
5728087
5729653
-
Sssca1
19
5728088
5731732
-
Ltbp3
19
5740904
5758532
+
Scyl1
19
5758427
5771401
-
Frmd8
19
5849702
5875274
-
Slc25a45
19
5877808
5885766
+
Tigd3
19
5891139
5894107
-
Dpf2
19
5896516
5913010
-
Cdc42ep2
19
5917556
5924816
-
Pola2
19
5940543
5964206
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5223D007246
Disease Name:infertilityInfertility
Category:Disease OntologyMeSH
Type:disease of anatomical entityMale Urogenital Diseases//Female Urogenital Diseases and Pregnancy Complications
Define:N/AA reduced or absent capacity to reproduce.
Alias:N/ASterility, Reproductive//Sterility//Reproductive Sterility//Subfertility//Sub-Fertility

 

Evidence Support

Strong Evidence:ISH//qPCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:25359727
Disease Name:infertility
Sample:N/A
Dysfunction Pattern:N/A
Validated Method:ISH//qPCR
Description:Neat1 knockout (KO) mice stochastically fail to become pregnant despite normal ovulation. Unilateral transplantation of wild-type ovaries or the administration of progesterone partially rescued the phenotype,suggesting that corpus luteum dysfunction and concomitant low progesterone were the primary causes of the decreased fertility. In contrast to the faint expression observed in most of the adult tissues,Neat1 was highly expressed in the corpus luteum,and the formation of luteal tissue was severely impaired in nearly half of the Neat1 KO mice
Author:Nakagawa S,Shimada M,Yanaka K,Mito M,Arai T,Takahashi E,Fujita Y,Fujimori T,Standaert L,Marine JC,Hirose T
Year:2014
Title:The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice.
Causality:Yes