Entry Detail



General Information

Database ID:LDA0006821
Species:Mus musculus
Confidence Score:0.982
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:Snhg1
Full Name:small nucleolar RNA host gene 1
Category:lncRNA
Species:Mus musculus
Synonyms:N/A
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):8723475End Site(bp):8726443
Gene Summary:N/A
External Links:
Ensembl ID:ENSMUSG00000108414
HGNC ID:N/A
Entrez Gene:83673
VEGA ID:OTTMUSG00000057839
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
Slc22a6
19
8617996
8628299
+
Chrm1
19
8663789
8683587
+
Slc3a2
19
8706882
8723369
-
Wdr74
19
8735827
8740624
+
Gm45736
19
8735841
8741223
+
1700092M07Rik
19
8740718
8741225
+
Stx5a
19
8741413
8756069
+
Nxf1
19
8757073
8772475
+
Taf6l
19
8772522
8786417
-
Polr2g
19
8793129
8798557
-
Zbtb3
19
8802530
8804854
+
Ttc9c
19
8809075
8819333
-
Hnrnpul2
19
8819401
8834142
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
Mir6992
19
8742971
8743079
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:LDA045N/A
Disease Name:ischemic strokeN/A
Category:LDAN/A
Type:N/AN/A
Define:N/AN/A
Alias:N/AN/A

 

Evidence Support

Strong Evidence:Luciferase reporter gene assay//RIP//RT-PCR//Western blot
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:29377234
Disease Name:ischemic stroke
Sample:solated cerebral micro-vessels of a middle cerebral artery occlusion (MCAO) mice model, and in oxygen-glucose deprivation (OGD)-cultured mice brain micro-vascular endothelial cells (BMECs)
Dysfunction Pattern:Expression [high expression]
Validated Method:RT-PCR//Luciferase reporter gene assay//Western blot//RIP
Description:In the present study, we found that SNHG1 expression was remarkably increased both in isolated cerebral micro-vessels of a middle cerebral artery occlusion (MCAO) mice model, and in oxygen-glucose deprivation (OGD)-cultured mice brain micro-vascular endothelial cells (BMECs), meanwhile, the SNHG1 level was negatively correlated with miR-18a in MCAO mice. Mechanistically, SNHG1 inhibition presents larger brain infarct size and worsens neurological scores in MCAO mice. Consistent with the in vivo findings, SNHG1 inhibition also significantly increased caspase-3 activity and cell apoptosis in OGD-cultured BMECs. Furthermore, we found that SNHG1 functions as a competing endogenous RNA (ceRNA) for miR-18a, thereby regulating the de-repression of its endogenous target HIF-1α and promoting BMEC survival through HIF-1α/VEGF signaling.
Author:Zhang L,Luo X,Chen F,Yuan W,Xiao X,Zhang X,Dong Y,Zhang Y,Liu Y
Year:2018
Title:LncRNA SNHG1 regulates cerebrovascular pathologies as a competing endogenous RNA through HIF-1α/VEGF signaling in ischemic stroke.
Causality:Yes