Entry Detail

General Information

Database ID:LDA0006836
Species:Mus musculus
Confidence Score:0.8785
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference


ncRNA Information

ncRNA Symbol:Gm14005
Full Name:N/A
Species:Mus musculus
Start Site(bp):0End Site(bp):0
Gene Summary:N/A
External Links:
Ensembl ID:N/A
Entrez Gene:N/A
RefSeq Accession:N/A


Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A


Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2377D009103
Disease Name:multiple sclerosisMultiple Sclerosis
Category:Disease OntologyMeSH
Type:disease of anatomical entityNervous System Diseases//Immune System Diseases
Define:A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Alias:Generalized multiple sclerosis (disorder)//insular sclerosisSclerosis, Multiple//Sclerosis, Disseminated//Disseminated Sclerosis//MS (Multiple Sclerosis)


Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:Microarray
Prediction Method:N/A



[1] PubMed ID:29518786
Disease Name:multiple sclerosis
Sample:EAE mice and activated astrocytes
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:qRT-PCR//Microarray
Description:12 lncRNAs were validated through real-time PCR. Gene ontology and KEGG pathway analysis were applied to explore the potential functions of lncRNAs. Differentially expressed 3300 lncRNAs and 3250 mRNAs were in the brain tissues of EAE mice, and 3748 lncRNAs and 3332 mRNAs were in activated astrocytes. Notably, there were 2 co-up-regulated lncRNAs and 3 co-down-regulated lncRNAs both in the brain tissues of EAE mice and in activated astrocytes, including Gm14005, Gm12478, mouselincRNA1117, AK080435, and mouselincRNA0681, which regulate the ER calcium flux kinetics, zinc finger protein and cell apoptosis. Similarly, there were 7 mRNAs co-up-regulated and 2 mRNAs co-down-regulated both in vivo and in vitro. Gene ontology and KEGG pathway analysis showed that the biological functions of differentially expressed mRNAs were associated with metabolism, development and inflammation. The results of realtime PCR validation were consistent with the data from the microarrays.
Author:Liu X,Zhang Q,Wang W,Zuo D,Wang J,Zhou F,Niu L,Li X,Qin S,Kou Y,Kong F,Pan W,Wang Y,Gao D,Sun H,Meves JM,Zheng K,Tang R
Title:Analysis of Long Noncoding RNA and mRNA Expression Profiles in IL-9-Activated Astrocytes and EAE Mice.