Entry Detail



General Information

Database ID:LDA0007020
Species:Rattus norvegicus
Confidence Score:0.9526
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:Malat1
Full Name:N/A
Category:lncRNA
Species:Rattus norvegicus
Synonyms:N/A
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497688End Site(bp):65506516
Gene Summary:N/A
External Links:
Ensembl ID:N/A
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:LDA008N/A
Disease Name:acute spinal cord injuryN/A
Category:LDAN/A
Type:N/AN/A
Define:N/AN/A
Alias:N/AN/A

 

Evidence Support

Strong Evidence:RIP//RNA pull-down assay//RT-qPCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:29631367
Disease Name:acute spinal cord injury
Sample: ASCI models in adult rats
Dysfunction Pattern:Expression [high expression]
Validated Method:RT-qPCR//RNA pull-down assay//RIP
Description:In the present study, MALAT1 expression was significantly increased (2.4-fold that of control) in the spinal cord of the rat contusion epicenter accompanied by activation of IKKβ/NF-κB signaling pathway and an increase in the level of proinflammatory cytokines TNF-α and IL-1β. Upon treatment with LPS, MALAT1 expression dramatically increased in the microglia in vitro, but knockdown of MALAT1 attenuated LPS-induced activation of MGs and TNF-α and IL-1β production. Next, we confirmed that LPS-induced MALAT1 activated IKKβ/NF-κB signaling pathway and promoted the production of proinflammatory cytokines TNF-α and IL-1β through down-regulating miR-199b. More importantly, MALAT1 knockdown gradually improved the hindlimb locomotor activity of ASCI rats, as well as inhibited TNF-α, IL-1β levels and Iba-1 protein, the marker of activated microglia in injured spinal cords.
Author:Zhou HJ,Wang LQ,Wang DB,Yu JB,Zhu Y,Xu QS,Zheng XJ,Zhan RY
Year:2018
Title:Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKβ/NF-κB signaling pathway.
Causality:Yes