Entry Detail



General Information

Database ID:LDA0007033
Species:Rattus norvegicus
Confidence Score:0.8808
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript (non-protein coding)
Category:lncRNA
Species:Rattus norvegicus
Synonyms:ASM//ASM1//D11S813E//H19 fetal liver mRNA//H19 fetal liver mRNA (mapped)//H19, imprinted maternally expressed transcript//H19_mapped
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):215744404End Site(bp):215747080
Gene Summary:INVOLVED IN in utero embryonic development; liver development; mesenchymal to epithelial transition; ASSOCIATED WITH Carcinoma, Hepatocellular; Carcinoma, Transitional Cell; Liver Neoplasms, Experimental
External Links:
Ensembl ID:N/A
HGNC ID:N/A
Entrez Gene:309122
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
Lsp1
1
215628785
215662504
+
AC132720.2
1
215659713
215660492
-
Tnnt3
1
215666628
215683628
+
Mrpl23
1
215701544
215709313
+
Igf2
1
215828102
215846911
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
Mir675
1
215745981
215746064
-
Mir483
1
215832088
215832160
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:12700D006966
Disease Name:hyperprolactinemiaHyperprolactinemia
Category:Disease OntologyMeSH
Type:disease of metabolismNervous System Diseases//Endocrine System Diseases
Define:An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
Alias:Chiari-Frommel syndrome//hyperprolactinaemia//Pregnancy-related A-G syndrome (disorder)Hyperprolactinemias//Prolactin, Inappropriate Secretion//Inappropriate Secretion Prolactin//Secretion Prolactin, Inappropriate//Inappropriate Prolactin Secretion Syndrome//Prolactin Hypersecretion Syndrome//Hypersecretion Syndrome, Prolactin//Syndrome, Prolactin Hypersecretion//Hyperprolactinaemia//Inappropriate Prolactin Secretion//Prolactin Secretion, Inappropriate//Secretion, Inappropriate Prolactin

 

Evidence Support

Strong Evidence:ISH//sqPCR
Weak Evidence:N/A
Prediction Method:N/A

 

Reference

[1] PubMed ID:15525575
Disease Name:hyperprolactinemia
Sample:prostate
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:ISH//sqPCR
Description:prolactin(PRL) upregulated the H19 expression in LNCaP cells by the JAK2-STAT5 transduction pathway.
Author:Berteaux N,Lottin S,Adriaenssens E,Van Coppenolle F,Leroy X,Coll J,Dugimont T,Curgy JJ
Year:2004
Title:Hormonal regulation of H19 gene expression in prostate epithelial cells.
Causality:No