Entry Detail



General Information

Database ID:LDA0007042
Species:Rattus norvegicus
Confidence Score:0.8785
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:Gfap
Full Name:glial fibrillary acidic protein
Category:lncRNA
Species:Rattus norvegicus
Synonyms:N/A
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):90990762End Site(bp):90999506
Gene Summary:ENCODES a protein that exhibits integrin binding; kinase binding; structural constituent of cytoskeleton; INVOLVED IN positive regulation of glial cell proliferation; regulation of chaperone-mediated autophagy; response to wounding; PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH Brain Edema; Head Injuries, Closed; Hyperalgesia; FOUND IN astrocyte projection; cytoplasmic side of lysosomal membrane; astrocyte end-foot (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (RS)-amphetamine; 1,3,5-trinitro-1,3,5-triazinane
External Links:
Ensembl ID:ENSRNOG00000002919
HGNC ID:N/A
Entrez Gene:24387
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:P47819

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
Gjc1
10
90781402
90912287
-
Higd1b
10
90929423
90931639
+
Eftud2
10
90932075
90983928
-
Ccdc103
10
90984227
90987823
+
FAM187A
10
90988732
90990203
+
Kif18b
10
91008269
91027738
-
C1ql1
10
91040005
91047177
-
Dcakd
10
91095545
91122018
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3525D020244
Disease Name:middle cerebral artery infarctionInfarction, Middle Cerebral Artery
Category:Disease OntologyMeSH
Type:disease of anatomical entityNervous System Diseases//Cardiovascular Diseases
Define:N/ANECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Alias:N/AMiddle Cerebral Artery Circulation Infarction//Middle Cerebral Artery Infarction//Cerebral Infarction, Middle Cerebral Artery//Stroke, Middle Cerebral Artery//MCA Infarction//Middle Cerebral Artery Stroke//Left Middle Cerebral Artery Infarction//Middle Cerebral Artery Embolus//Embolus, Middle Cerebral Artery//Middle Cerebral Artery Occlusion//Occlusion, Middle Cerebral Artery//Thrombotic Infarction, Middle Cerebral Artery//Middle Cerebral Artery Thrombotic Infarction//Middle Cerebral Artery Thrombosis//Thrombosis, Middle Cerebral Artery//Right Middle Cerebral Artery Infarction//Embolic Infarction, Middle Cerebral Artery//Middle Cerebral Artery Embolic Infarction//Middle Cerebral Artery Syndrome

 

Evidence Support

Strong Evidence:RIP
Weak Evidence:Microarray
Prediction Method:N/A

 

Reference

[1] PubMed ID:24063527
Disease Name:middle cerebral artery infarction
Sample:brain
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:RIP//Microarray
Description:Three lncRNAs showed increased binding to both Sin3A and coREST,as well as increased expression after focal ischemia compared with sham. A further 23 lncRNAs that showed increased binding to Sin3A and eight lncRNAs that showed increased binding to coREST were also significantly up-regulated after focal ischemia compared with sham.
Author:Dharap A,Pokrzywa C,Vemuganti R
Year:2013
Title:Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST.
Causality:No