Entry Detail



General Information

Database ID:LDA0007225
Species:Homo sapiens
Confidence Score:0.6308
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:KCNQ1DN
Full Name:KCNQ1 downstream neighbor (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:BWRT//HSA404617
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):2870033End Site(bp):2872105
Gene Summary:Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2; MIM 194071) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele (Xin et al., 2000 [PubMed 11056398]).[supplied by OMIM, Mar 2008]
External Links:
Ensembl ID:ENSG00000237941
HGNC ID:HGNC:13335
Entrez Gene:55539
VEGA ID:OTTHUMG00000009942
UCSC ID:uc009ydq.4
ENA:AB039920
RefSeq Accession:NR_024627
UniProtKB:Q9H478

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KCNQ1
11
2444684
2849110
+
CDKN1C
CHR_HSCHR11_1_CTG7
2883205
2885904
-
SLC22A18AS
11
2887780
2903740
-
SLC22A18
11
2899721
2925246
+
PHLDA2
CHR_HSCHR11_1_CTG7
2928201
2929383
-
NAP1L4
CHR_HSCHR11_1_CTG7
2943292
2991260
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000375N/A
Disease Name:AgingN/A
Category:MeSHN/A
Type:Physiological PhenomenaN/A
Define:The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.N/A
Alias:Senescence//Biological Aging//Aging, BiologicalN/A

 

Evidence Support

Strong Evidence:N/A
Weak Evidence:Bioinformatic analysis
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:22067257
Disease Name:Aging
Sample:N/A
Dysfunction Pattern:Epigenetics
Validated Method:Bioinformatic analysis
Description:Continuously hypermethylated upon aging.
Author:Koch CM,Wagner W
Year:2011
Title:Epigenetic-aging-signature to determine age in different tissues.
Causality:No