Entry Detail



General Information

Database ID:LDA0007258
Species:Homo sapiens
Confidence Score:0.7802
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:AC091891.2
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):2712591End Site(bp):2715237
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000281560
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
IRX2
5
2745845
2751662
-
C5orf38
5
2752131
2755397
+
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Skin and Connective Tissue Diseases
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerTumors, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Neoplasms, Breast//Breast Neoplasm//Neoplasm, Breast//Breast Cancer//Cancer, Breast//Cancer of the Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human

 

Evidence Support

Strong Evidence:Immunoblot
Weak Evidence:N/A
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:20214974
Disease Name:breast cancer
Sample:cell line (HMEC, HCC1500, HCC1569)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Immunoblot
Description:Collectively,our results identified a new class of long stress responsive non-coding transcripts,LSINCTs,which have increased expression in response to DNA damage induced by NNK. LSINCTs interestingly also have increased expression in a number of cancer-derived cell lines,indicating that the expression is increased in both,correlating cellular stress and cancer.
Author:Silva JM,Perez DS,Pritchett JR,Halling ML,Tang H,Smith DI
Year:2010
Title:Identification of long stress-induced non-coding transcripts that have altered expression in cancer.
Causality:No

[2] PubMed ID:21532345
Disease Name:breast cancer
Sample:cell line (HMEC, MCF7, MDA157)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Immunoblot
Description:LSINCT5 is overexpressed in breast and ovarian cancer cell lineand tumor tissues,relative to their normal counterpart. In addition,knocking down the expression of LSINCT5 in cancer-derived cell linecauses a decrease in cellular proliferation. Two genes that were significantly downregulated were the lncRNA NEAT-1 and a protein coding gene PSPC1. We have therefore characterized a novel lncRNA that is overexpressed in breast and ovarian cancers,enhances cellular proliferation and may play a significant role in multiple processes.
Author:Silva JM,Boczek NJ,Berres MW,Ma X,Smith DI
Year:2011
Title:LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation.
Causality:Yes

[3] PubMed ID:22817756
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Immunoblot
Description:Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA, this transcript acts to target several other transcripts,including the antisense RNA NEAT-1 and the PSPC1 gene,which codes for a splicing regulatory factor
Author:Harries LW
Year:2012
Title:Long non-coding RNAs and human disease.
Causality:No