Entry Detail



General Information

Database ID:LDA0007313
Species:Homo sapiens
Confidence Score:0.9833
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:SPRY4-IT1
Full Name:SPRY4 intronic transcript 1
Category:lncRNA
Species:Homo sapiens
Synonyms:SPRIGHTLY
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):142317620End Site(bp):142318322
Gene Summary:This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (sprouty RTK signaling antagonist 4). [provided by RefSeq, Feb 2016]
External Links:
Ensembl ID:ENSG00000281881
HGNC ID:HGNC:42394
Entrez Gene:100642175
VEGA ID:OTTHUMG00000189512
UCSC ID:uc063iel.1
ENA:AK024556
RefSeq Accession:NR_131221
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SPRY4
5
142310427
142326455
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Skin and Connective Tissue Diseases
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerTumors, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Neoplasms, Breast//Breast Neoplasm//Neoplasm, Breast//Breast Cancer//Cancer, Breast//Cancer of the Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human

 

Evidence Support

Strong Evidence:qPCR//RNAi//Western blot
Weak Evidence:Microarray
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:25742952
Disease Name:breast cancer
Sample:tissue, cell line (MD-MB-231, MD-MB-435S, MCF-10A, MCF-7)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//RNAi//Western blot//Microarray
Description:SPRY4-IT1 expression was significantly upregulated in 48 breast cancer tumor tissues comparedwith normal tissues. Additionally,increased SPRY4-IT1 expression was found to be associated with a larger tumor size and an advanced pathological stage in breast cancer patients. SPRY4-IT1 is a novel prognostic biomarker and a potential therapeutic candidate for breast cancer.
Author:Shi Y,Li J,Liu Y,Ding J,Fan Y,Tian Y,Wang L,Lian Y,Wang K,Shu Y
Year:2015
Title:The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.
Causality:Yes