Entry Detail



General Information

Database ID:LDA0007314
Species:Homo sapiens
Confidence Score:0.6308
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:SRA1
Full Name:steroid receptor RNA activator 1
Category:lncRNA
Species:Homo sapiens
Synonyms:SRA//STRAA1
Chromosome:5
Strand:-
Coordinate:
Start Site(bp):140537340End Site(bp):140558252
Gene Summary:Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
External Links:
Ensembl ID:ENSG00000213523
HGNC ID:HGNC:11281
Entrez Gene:10011
VEGA ID:OTTHUMG00000163569
UCSC ID:uc003lga.4
ENA:AF092038
RefSeq Accession:NM_001035235
UniProtKB:Q9HD15

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANKHD1
5
140401814
140539856
+
ANKHD1-EIF4EBP3
5
140401908
140549569
+
EIF4EBP3
5
140547666
140549578
+
APBB3
5
140558268
140564781
-
SLC35A4
5
140564456
140569103
+
CD14
5
140631728
140633701
-
NDUFA2
5
140638740
140647785
-
TMCO6
5
140639427
140645408
+
IK
5
140647058
140662479
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR6831
5
140563671
140563751
-
MIR3655
5
140647844
140647926
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Skin and Connective Tissue Diseases
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerTumors, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Neoplasms, Breast//Breast Neoplasm//Neoplasm, Breast//Breast Cancer//Cancer, Breast//Cancer of the Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human

 

Evidence Support

Strong Evidence:N/A
Weak Evidence:Array
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:10485452
Disease Name:breast cancer
Sample:breast tissue
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:Changes in the expression of sra-related molecules occur during breast tumor progression.
Author:Leygue E,Dotzlaw H,Watson PH,Murphy LC
Year:1999
Title:Expression of the steroid receptor RNA activator in human breast tumors.
Causality:No

[2] PubMed ID:12565891
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Array
Description:Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines.
Author:Emberley E,Huang GJ,Hamedani MK,Czosnek A,Ali D,Grolla A,Lu B,Watson PH,Murphy LC,Leygue E
Year:2003
Title:Identification of new human coding steroid receptor RNA activator isoforms.
Causality:No

[3] PubMed ID:16152589
Disease Name:breast cancer
Sample:cell line (mcf7)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:The presence of both coding SRA rna and its corresponding srap modifies the activity of estrogen receptor in breast cancer cells and that SRAP could be a new clinical marker for breast cancer. Transient transfection experiments,performed using a luciferase reporter gene under the control of an estrogen-responsive element,revealed decreased sensitivity to estradiol but no additional sensitivity to tamoxifen in SRAP-overexpressing cells.
Author:Chooniedass-Kothari S,Hamedani MK,Troup S,Hubé F,Leygue E
Year:2006
Title:The steroid receptor RNA activator protein is expressed in breast tumor tissues.
Causality:No

[4] PubMed ID:16848684
Disease Name:breast cancer
Sample:cell line (BT-20, MDA-MB-469, MDA-MB-231)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:We recently reported a decreased estrogen receptor activity in breast cancer cells overexpressing SRAP,suggesting antagonist roles played by SRA1 RNA and SRAP. The primary genomic sequence in and around intron-1 is sufficient to lead to a differential splicing of this intron. We propose that alternative splicing of intron-1 is one mechanism used by breast cancer cells to regulate the balance between coding and functional noncoding SRA1 RNAs.
Author:Hube F,Guo J,Chooniedass-Kothari S,Cooper C,Hamedani MK,Dibrov AA,Blanchard AA,Wang X,Deng G,Myal Y,Leygue E
Year:2006
Title:Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines.
Causality:No

[5] PubMed ID:17710122
Disease Name:breast cancer
Sample:breast cancer cell
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:The published literature dealing with these two faces of the sra gene products and underscores the relevance of this bifaceted system to breast cancer development. Using RT-PCR targeting core SRA sequences,several reports have shown that SRA expression was increased during breast,uterus and ovarian tumorigenesis.
Author:Leygue E
Year:2007
Title:Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer.
Causality:No

[6] PubMed ID:19483093
Disease Name:breast cancer
Sample:tissue, cell line (T5)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:We report a significant higher SRA-intron-1 relative expression in breast tumors with higher progesterone receptor contents. Using an antisense oligoribonucleotide,we have successfully reprogrammed endogenous SRA splicing and increased SRA RNA-intron-1 relative level in T5 breast cancer cells. Our results suggest that the balance coding/non-coding SRA transcripts not only characterizes particular tumor phenotypes but might also,through regulating the expression of specific genes,be involved in breast tumorigenesis and tumor progression.
Author:Cooper C,Guo J,Yan Y,Chooniedass-Kothari S,Hube F,Hamedani MK,Murphy LC,Myal Y,Leygue E
Year:2009
Title:Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.
Causality:No

[7] PubMed ID:19483093
Disease Name:breast cancer
Sample:breast cancer cell
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:We have successfully reprogrammed endogenous SRA splicing and increased SRA RNA-intron-1 relative level in T5 breast cancer cells. This increase is paralleled by significant changes in the expression of genes such as plasminogen urokinase activator and estrogen receptor beta. Estrogen regulation of other genes,including the anti-metastatic NME1 gene,is also altered.
Author:Cooper C,Guo J,Yan Y,Chooniedass-Kothari S,Hube F,Hamedani MK,Murphy LC,Myal Y,Leygue E
Year:2009
Title:Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.
Causality:No

[8] PubMed ID:20079837
Disease Name:breast cancer
Sample:cell line (HEK293T)
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Array
Description:Disturbance of the balance between SRAP1-coding and non-coding SRA1 RNAs in breast tumor tissues might be involved in breast tumorigenesis.
Author:Borth N,Massier J,Franke C,Sachse K,Saluz HP,Hänel F
Year:2010
Title:Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity.
Causality:No

[9] PubMed ID:20219889
Disease Name:breast cancer
Sample:cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:Eight bona fide SRA downstream target genes were identified (SLC2A3,SLC2A12,CCL20,TGFB2,DIO2,TMEM65,TBL1X,and TMPRSS2),representing entirely novel SRA targets,except for TMPRSS2. SRA RNA is overexpressed in breast,uterine,and ovarian tumors and affects the growth of certain hormone-dependent breast and prostate cancer cell lines.
Author:Foulds CE,Tsimelzon A,Long W,Le A,Tsai SY,Tsai MJ,O'Malley BW
Year:2010
Title:Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene.
Causality:Yes

[10] PubMed ID:22362738
Disease Name:breast cancer
Sample:cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:Additionally,the relative ratio of SRA/SRAP expression differs in breast cancer tumor cells,with higher recovery rates for patients for whom SRAP is overexpressed.
Author:Novikova IV,Hennelly SP,Sanbonmatsu KY
Year:2012
Title:"Structural architecture of the human long non-coding RNA, steroid receptor RNA activator."
Causality:No

[11] PubMed ID:22664915
Disease Name:breast cancer
Sample:breast cancer cell
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Array
Description:Elevated levels of SRA are found in breast tumors and the increased SRA levels might contribute to the altered ER/PR action that occurs during breast tumorigenesis.
Author:Gutschner T,Diederichs S
Year:2012
Title:The hallmarks of cancer: a long non-coding RNA point of view.
Causality:No

[12] PubMed ID:24499465
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Array
Description:Co-activator of steroid Receptors & other transcription Factors, associate with metastasis
Author:Jiang YJ,Bikle DD
Year:2014
Title:"LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation."
Causality:No