Entry Detail



General Information

Database ID:LDA0007318
Species:Homo sapiens
Confidence Score:0.9993
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:UCA1
Full Name:urothelial cancer associated 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:LINC00178//CUDR//UCAT1//onco-lncRNA-36
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):15828961End Site(bp):15836320
Gene Summary:This gene represents a long non-coding RNA. It plays a regulatory role in bladder cancer cell proliferation. Several genes can be regulated by this gene, and the most important one is the CREB (cAMP responsive element binding protein) gene, which encodes a transcriptional factor and affects the oncogenesis. [provided by RefSeq, Mar 2012]
External Links:
Ensembl ID:ENSG00000214049
HGNC ID:HGNC:37126
Entrez Gene:652995
VEGA ID:OTTHUMG00000182287
UCSC ID:uc002nbr.5
ENA:BC005351
RefSeq Accession:NR_015379
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
OR10H2
19
15728020
15729060
+
OR10H3
19
15737985
15742343
+
OR10H5
19
15787661
15801025
+
OR10H1
19
15804549
15815664
-
CYP4F2
19
15878023
15898120
-
CYP4F11
19
15912367
15934867
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Skin and Connective Tissue Diseases
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerTumors, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Neoplasms, Breast//Breast Neoplasm//Neoplasm, Breast//Breast Cancer//Cancer, Breast//Cancer of the Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human

 

Evidence Support

Strong Evidence:IF//Knockdown//Luciferase reporter gene assay//qPCR//qRT-PCR//RT-PCR//Western blot
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:16914571
Disease Name:breast cancer
Sample:breast cancer cell
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:IF//RT-PCR
Description:The low expression rate in other cancer types,especially in renal cancers,makes UCA1 more discriminative in the diagnosis of TCC. Expression of UCA1 in various cancerous tissues and cell lineevaluated by RT-PCR.
Author:Wang XS,Zhang Z,Wang HC,Cai JL,Xu QW,Li MQ,Chen YC,Qian XP,Lu TJ,Yu LZ,Zhang Y,Xin DQ,Na YQ,Chen WF
Year:2006
Title:Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma.
Causality:No

[2] PubMed ID:24457952
Disease Name:breast cancer
Sample:cell line ( MCF-7, MDA-MB-231, HCT-116 p53-WT, HCT-116)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:IF//RT-PCR
Description:We found that UCA1 was upregulated in breast tumors compared with the normal breast tissue. In contrast,p27 was downregulated in breast tumors,which was derived from the same core. This negative correlation between UCA1 and p27 was further supported by the data from breast cancer TMA.
Author:Huang J,Zhou N,Watabe K,Lu Z,Wu F,Xu M,Mo YY
Year:2014
Title:Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1).
Causality:No

[3] PubMed ID:26439035
Disease Name:breast cancer
Sample:tissue, cell lines (MDA-MB-231)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:IF//RT-PCR
Description:UC1 was significantly upregulated,while miR-143 was significantly downregulated in the tumor tissues than in the adjacent normal tissues. There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC),through association with miR-143. Through downregulating miR-143,UCA1 can modulate breast cancer cell growth and apoptosis
Author:Tuo YL,Li XM,Luo J
Year:2015
Title:Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143.
Causality:Yes

[4] PubMed ID:26464647
Disease Name:breast cancer
Sample:breast tissue
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:IF//RT-PCR
Description:We found that treatment with macrophage CM induced the expression of numerous lncRNAs,including urothelial cancer associated 1 (UCA1). Knockdown of UCA1 using shRNA inhibited AKT phosphorylation and abolished invasiveness of tumor cells induced by macrophage CM.Consistent with these results, we further showed that UCA1 level was significantly enhanced in human primary breast tumors and correlated with advanced clinical stage,supporting its role in promoting carcinogenesis and progression of breast cancer
Author:Chen S,Shao C,Xu M,Ji J,Xie Y,Lei Y,Wang X
Year:2015
Title:Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1.
Causality:Yes

[5] PubMed ID:27424981
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Regulation
Validated Method:IF//RT-PCR
Description:LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.
Author:Xiao C,Wu CH,Hu HZ
Year:2016
Title:LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.
Causality:Yes

[6] PubMed ID:27629141
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Regulation
Validated Method:IF//RT-PCR
Description:Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1α feedback regulatory loop.
Author:Li X,Wu Y,Liu A,Tang X
Year:2016
Title:Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1α feedback regulatory loop.
Causality:No

[7] PubMed ID:27697109
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Expression
Validated Method:IF//RT-PCR
Description:UCA1 was upregulated by SATB1 depletion and SATB1 is highly expressed in aggressive breast cancer cells and promotes growth and metastasis by reprograming gene expression.
Author:Lee JJ,Kim M,Kim HP
Year:2016
Title:Epigenetic regulation of long noncoding RNA UCA1 by SATB1 in breast cancer.
Causality:No

[8] PubMed ID:27765938
Disease Name:breast cancer
Sample:N/A
Dysfunction Pattern:Regulation
Validated Method:IF//RT-PCR
Description:UCA1 confers tamoxifen resistance to breast cancer cells partly via activating the mTOR signaling pathway.
Author:Wu C,Luo J
Year:2016
Title:Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway.
Causality:No

[9] PubMed ID:27831634
Disease Name:breast cancer
Sample:breast cancer cells
Dysfunction Pattern:Expression [high expression]
Validated Method:qRT-PCR
Description:MCF-7 cells pretreated with exos/LCC2 had a significantly increased cell viability, a decreased expression of cleaved caspase-3 and a lower ratio of apoptosis after tamoxifen treatment. The exos/LCC2 with impaired UCA1 loading had significantly suppressed capability to promote tamoxifen resistance in MCF-7 cells.
Author:Xu CG,Yang MF,Ren YQ,Wu CH,Wang LQ
Year:2016
Title:Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells.
Causality:No

[10] PubMed ID:27977766
Disease Name:breast cancer
Sample:BC cell lines
Dysfunction Pattern:Expression [high expression]
Validated Method:qPCR//Western blot//Knockdown
Description:We found that the expression of UCA1 positively correlated with the pathological grade and mortality of breast cancer patients, moreover, expressions of UCA1 was increased significantly in the tamoxifen-resistant cell lines compared with the wild type parental cells.
Author:Liu H,Wang G,Yang L,Qu J,Yang Z,Zhou X
Year:2016
Title:Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/β-Catenin Pathway.
Causality:Yes

[11] PubMed ID:29408336
Disease Name:breast cancer
Sample:breast cancer cells
Dysfunction Pattern:Regulation
Validated Method:Luciferase reporter gene assay//Knockdown
Description:Here, we found that knockdown of the long non-coding RNA, urothelial cancer associated 1 (UCA1), can promote the sensitivity of human breast cancer cells to trastuzumab. Mechanistically, UCA1 knockdown upregulated miR-18a and promoted miR-18a repression of Yes-associated protein 1 (YAP1). A luciferase reporter assay confirmed the association of miR-18a with wild-type UCA1 but not with UCA1 mutated at the predicted miR-18a-binding site. The direct targeting of YAP1 by miR-18a was verified by the observation that miR-18a mimic suppressed luciferase expression from a construct containing the YAP1 3' untranslated region. Meanwhile, reciprocal repression of UCA1 and miR-18a were found to be Argonaute 2-dependent. Knockdown of YAP1 recapitulated the effect of UCA1 silencing by reducing the viability of trastuzumab-treated breast cancer cells, whereas inhibition of miR-18a abrogated UCA1 knockdown-induced improvement of trastuzumab sensitivity in breast cancer cells.
Author:Zhu HY,Bai WD,Ye XM,Yang AG,Jia LT
Year:2018
Title:Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1.
Causality:Yes