Entry Detail



General Information

Database ID:LDA0007322
Species:Homo sapiens
Confidence Score:0.963
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:TncRNA//MENepsilon/beta//LINC00084//VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422774End Site(bp):65445540
Gene Summary:This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
External Links:
Ensembl ID:ENSG00000245532
HGNC ID:HGNC:30815
Entrez Gene:283131
VEGA ID:OTTHUMG00000166321
UCSC ID:uc010rog.3
ENA:AF080092
RefSeq Accession:NR_028272
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DPF2
11
65333754
65353249
+
TIGD3
11
65354767
65357613
+
SLC25A45
11
65375192
65383701
-
FRMD8
11
65386599
65413525
+
SCYL1
11
65525077
65538704
+
LTBP3
11
65538805
65558930
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR612
11
65444458
65444557
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8584D002051
Disease Name:Burkitt lymphomaBurkitt Lymphoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationVirus Diseases//Neoplasms//Hemic and Lymphatic Diseases//Immune System Diseases
Define:A mature B-cell neoplasm of B-cells found in the germinal center.A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Alias:Burkitt lymphoma/leukaemia//Burkitt's Lymphoma//Burkitt's tumor//Burkitt's tumor or lymphoma//malignant lymphoma, Burkitt's type//small Non-Cleaved cell Lymphoma, Burkitt's typeBurkitt Leukemia//Leukemia, Burkitt//Leukemia, Lymphoblastic, Burkitt-Type//Burkitt's Lymphoma//Burkitts Lymphoma//Lymphoma, Burkitt's//Burkitt Cell Leukemia//Cell Leukemia, Burkitt//Leukemia, Burkitt Cell//Burkitt's Tumor//Burkitts Tumor//Tumor, Burkitt's//Burkitt Tumor//Tumor, Burkitt//Leukemia, Lymphocytic, L3//Lymphocytic Leukemia, L3//L3 Lymphocytic Leukemia//L3 Lymphocytic Leukemias//Leukemia, L3 Lymphocytic//Leukemias, L3 Lymphocytic//Lymphocytic Leukemias, L3//Burkitt's Leukemia//Burkitts Leukemia//Leukemia, Burkitt's//Lymphoma, Burkitt//African Lymphoma//Lymphoma, African

 

Evidence Support

Strong Evidence:qPCR//RNAi//Western blot
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:25971364
Disease Name:Burkitt lymphoma
Sample:blood
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//RNAi//Western blot
Description:NEAT1 expression levels were validated by qPCR,demonstrating high baseline expression (average Cp = 21.3),and confirming p53-dependent induction .lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma.
Author:Blume CJ,Hotz-Wagenblatt A,Hüllein J,Sellner L,Jethwa A,Stolz T,Slabicki M,Lee K,Sharathchandra A,Benner A,Dietrich S,Oakes CC,Dreger P,te Raa D,Kater AP,Jauch A,Merkel O,Oren M,Hielscher T,Zenz T
Year:2015
Title:p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.
Causality:No