Entry Detail



General Information

Database ID:LDA0007363
Species:Homo sapiens
Confidence Score:0.9007
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:lncRNA
Species:Homo sapiens
Synonyms:ANRIL//RP11-145E5.4//NCRNA00089//p15AS//CDKN2B-AS//PCAT12
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994778End Site(bp):22121097
Gene Summary:This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
External Links:
Ensembl ID:ENSG00000240498
HGNC ID:HGNC:34341
Entrez Gene:100048912
VEGA ID:OTTHUMG00000019689
UCSC ID:uc010miz.4
ENA:BC038540
RefSeq Accession:NR_003529
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MTAP
9
21802543
21937651
+
AL359922.1
9
21802636
22032986
+
CDKN2A
9
21967753
21995301
-
CDKN2B
9
22002903
22009363
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1287D002318
Disease Name:cardiovascular system diseaseCardiovascular Diseases
Category:Disease OntologyMeSH
Type:disease of anatomical entityCardiovascular Diseases
Define:A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Alias:disease of subdivision of hemolymphoid systemCardiovascular Disease//Disease, Cardiovascular//Diseases, Cardiovascular

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:Array
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:23104877
Disease Name:cardiovascular system disease
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:qPCR//Array
Description:ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms,and it has been consistently associated with cardiovascular disease,and more recently with several cancers,diabetes,glaucoma,endometriosis among other conditions.
Author:Schonrock N,Harvey RP,Mattick JS
Year:2012
Title:Long noncoding RNAs in cardiac development and pathophysiology.
Causality:No

[2] PubMed ID:20716961
Disease Name:cardiovascular system disease
Sample:N/A
Dysfunction Pattern:Mutation
Validated Method:qPCR//Array
Description:Recent studies showed that single nucleotide polymorphisms (rs3217992,A>G,rs1063192,C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions,including cardiovascular disease,ischemic stroke,type 2 diabetes,frailty and Alzheimer's disease.
Author:Popov N,Gil J
Year:2010
Title:Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health.
Causality:No

[3] PubMed ID:22382030
Disease Name:cardiovascular system disease
Sample:cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//Array
Description:Anril splicing variants play a role in coordinating tissue remodeling,by modulating the expression of genes involved in cell proliferation,apoptosis,extra-cellular matrix remodeling and inflammatory response to finally impact in the risk of cardiovascular disease and other pathologies.
Author:Congrains A,Kamide K,Katsuya T,Yasuda O,Oguro R,Yamamoto K,Ohishi M,Rakugi H
Year:2012
Title:"CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC."
Causality:Yes

[4] PubMed ID:24113581
Disease Name:cardiovascular system disease
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:qPCR//Array
Description:Recently,ANRIL,a multi-exonic lncRNA,has been shown to be implicated in epigenetic modulation in cardiac development and adult heart and also it has been associated with a locus implicated in cardiovascular disease.
Author:Iaconetti C,Gareri C,Polimeni A,Indolfi C
Year:2013
Title:"Non-coding RNAs: the ""dark matter"" of cardiovascular pathophysiology."
Causality:No

[5] PubMed ID:24531795
Disease Name:cardiovascular system disease
Sample:N/A
Dysfunction Pattern:Mutation
Validated Method:qPCR//Array
Description:Aberrant ANRIL transcripts and mutations were associated with cardiovascular disease and cancer .
Author:Maass PG,Luft FC,Bähring S
Year:2014
Title:Long non-coding RNA in health and disease.
Causality:No