Entry Detail



General Information

Database ID:LDA0007366
Species:Homo sapiens
Confidence Score:0.7903
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:lncRNA
Species:Homo sapiens
Synonyms:HOXC-AS4//HOXC11-AS1//NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
Gene Summary:This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with HOXC genes. It represses transcription of HOXD genes on chromosome 2 in trans. This gene is shuttled from chromosome 12 to chromosome 2 by a component of Polycomb Repressive Complex 2 (PRC2). This gene interacts with both PRC2 and lysine specific demethylase 1 (LSD1) complexes through its 5' and 3' domains, respectively, and serves as a scaffold to assemble PRC2 and LSD1 complexes to the HOXD gene cluster. It couples H3K27 methylation and H3K4 demethylation for epigenetic silencing of HOXD genes in multiple tissues. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2013]
External Links:
Ensembl ID:ENSG00000228630
HGNC ID:HGNC:33510
Entrez Gene:100124700
VEGA ID:OTTHUMG00000152934
UCSC ID:uc009zne.5
ENA:DQ926657
RefSeq Accession:NR_003716
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HOXC13
12
53938765
53946544
+
HOXC12
12
53954834
53958956
+
HOXC11
12
53973126
53977643
+
HOXC10
12
53985065
53990279
+
AC012531.3
12
53985845
54034888
+
HOXC6
12
53990624
54030823
+
HOXC9
12
53994895
54003337
+
HOXC8
12
54009106
54012362
+
HOXC4
12
54016931
54056030
+
HOXC5
12
54032853
54035358
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR196A2
12
53991738
53991847
+
MIR615
12
54033950
54034045
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6713D020521
Disease Name:cerebrovascular diseaseStroke
Category:Disease OntologyMeSH
Type:disease of anatomical entityNervous System Diseases//Cardiovascular Diseases
Define:An artery disease that is characterized by dysfunction of the blood vessels supplying the brain.A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Alias:cerebrovascular accident//Cerebrovascular accident (disorder)//cerebrovascular disorder//CVA (cerebral vascular accident)//strokeStrokes//Cerebrovascular Accident//Cerebrovascular Accidents//CVA (Cerebrovascular Accident)//Cerebrovascular Apoplexy//Apoplexy, Cerebrovascular//Vascular Accident, Brain//Brain Vascular Accident//Brain Vascular Accidents//Vascular Accidents, Brain//Cerebrovascular Stroke//Cerebrovascular Strokes//Stroke, Cerebrovascular//Strokes, Cerebrovascular//Apoplexy//Cerebral Stroke//Cerebral Strokes//Stroke, Cerebral//Strokes, Cerebral//Stroke, Acute//Acute Stroke//Acute Strokes//Strokes, Acute//Cerebrovascular Accident, Acute//Acute Cerebrovascular Accident//Acute Cerebrovascular Accidents//Cerebrovascular Accidents, Acute

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:27613094
Disease Name:cerebrovascular disease
Sample:N/A
Dysfunction Pattern:Regulation
Validated Method:qPCR
Description:Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2.
Author:Yang L,Lu ZN
Year:2016
Title:Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2.
Causality:Yes