Entry Detail



General Information

Database ID:LDA0007377
Species:Homo sapiens
Confidence Score:0.7971
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:D11S813E//ASM//ASM1//NCRNA00008//LINC00008
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):1995163End Site(bp):2001470
Gene Summary:This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
External Links:
Ensembl ID:ENSG00000130600
HGNC ID:HGNC:4713
Entrez Gene:283120
VEGA ID:OTTHUMG00000012477
UCSC ID:uc057xvv.1
ENA:AF087017
RefSeq Accession:NR_002196
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TNNT3
11
1919562
1938706
+
MRPL23
11
1947278
1984522
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR675
11
1996759
1996831
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Female Urogenital Diseases and Pregnancy Complications
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix (disorder)//tumor of the Cervix Uteri//uterine cervical neoplasmCervical Neoplasm, Uterine//Cervical Neoplasms, Uterine//Neoplasm, Uterine Cervical//Neoplasms, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasm, Cervical//Neoplasms, Cervix//Cervix Neoplasms//Cervix Neoplasm//Neoplasm, Cervix//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cancers, Uterine Cervical//Cervical Cancer, Uterine//Cervical Cancers, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix//Cancers, Cervix

 

Evidence Support

Strong Evidence:ISH
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2//RWRlncD//TAM

 

Reference

[1] PubMed ID:8570220
Disease Name:cervical cancer
Sample:N/A
Dysfunction Pattern:Mutation
Validated Method:ISH
Description:High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas.
Author:Douc-Rasy S,Barrois M,Fogel S,Ahomadegbe JC,Stéhelin D,Coll J,Riou G
Year:1996
Title:High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19.
Causality:No

[2] PubMed ID:15525575
Disease Name:cervical cancer
Sample:cell lines
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:ISH
Description:Many types of cancer,such as breast,bladder,lung,esophagealand cervical,carcinomas exhibit H19 overexpression. To address the potential regulation of H19 gene expression by an androgen steroid hormone (DHT: dihydrotestosterone) or by a peptidic hormone (PRL: prolactin).
Author:Berteaux N,Lottin S,Adriaenssens E,Van Coppenolle F,Leroy X,Coll J,Dugimont T,Curgy JJ
Year:2004
Title:Hormonal regulation of H19 gene expression in prostate epithelial cells.
Causality:No