Entry Detail



General Information

Database ID:LDA0007382
Species:Homo sapiens
Confidence Score:0.9007
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:LINC01101
Full Name:long intergenic non-protein coding RNA 1101
Category:lncRNA
Species:Homo sapiens
Synonyms:FLJ14816
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):120464335End Site(bp):120466218
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000280409
HGNC ID:HGNC:25923
Entrez Gene:84931
VEGA ID:OTTHUMG00000187117
UCSC ID:N/A
ENA:AK027722
RefSeq Accession:NR_027181
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Female Urogenital Diseases and Pregnancy Complications
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix (disorder)//tumor of the Cervix Uteri//uterine cervical neoplasmCervical Neoplasm, Uterine//Cervical Neoplasms, Uterine//Neoplasm, Uterine Cervical//Neoplasms, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasm, Cervical//Neoplasms, Cervix//Cervix Neoplasms//Cervix Neoplasm//Neoplasm, Cervix//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cancers, Uterine Cervical//Cervical Cancer, Uterine//Cervical Cancers, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix//Cancers, Cervix

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:Microarray
Prediction Method:TAM

 

Reference

[1] PubMed ID:28767188
Disease Name:cervical cancer
Sample:HPV-induced neoplasia
Dysfunction Pattern:Expression [high expression]
Validated Method:qRT-PCR//Microarray
Description:After analysing the microarray results, we identified 15,387 RNA species differentially expressed in E7-siRNA-transfected cells compared with controls (fold change >2). The expression profiles of lncRNA species highlighted 731 lncRNAs and 203 lincRNAs. We selected two lincRNAs (LINC01101 and LINC00277) and we evaluated the expression profile in HPV-induced neoplasia. Both lincRNAs investigated display a significantly reduced pattern of expression in cervical lesions and cancer, associated with clinical parameters. A connection between HPV presence and lincRNAs was noted. hrHPV-positive samples exhibit significantly reduced LINC01101 and LINC00277 expression level (P < 0.05).
Author:Iancu IV,Anton G,Botezatu A,Huica I,Nastase A,Socolov DG,Stanescu AD,Dima SO,Bacalbasa N,Plesa A
Year:2017
Title:LINC01101 and LINC00277 expression levels as novel factors in HPV-induced cervical neoplasia.
Causality:Yes