Entry Detail



General Information

Database ID:LDA0007383
Species:Homo sapiens
Confidence Score:0.998
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:LINP1
Full Name:N/A
Category:lncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):6737382End Site(bp):6739026
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000223784
HGNC ID:N/A
Entrez Gene:N/A
VEGA ID:N/A
UCSC ID:N/A
ENA:N/A
RefSeq Accession:N/A
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Female Urogenital Diseases and Pregnancy Complications
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix (disorder)//tumor of the Cervix Uteri//uterine cervical neoplasmCervical Neoplasm, Uterine//Cervical Neoplasms, Uterine//Neoplasm, Uterine Cervical//Neoplasms, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasm, Cervical//Neoplasms, Cervix//Cervix Neoplasms//Cervix Neoplasm//Neoplasm, Cervix//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cancers, Uterine Cervical//Cervical Cancer, Uterine//Cervical Cancers, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix//Cancers, Cervix

 

Evidence Support

Strong Evidence:Flow Cytometry//IF staining//qRT-PCR//RIP//RNA pull-down assay//Western blot
Weak Evidence:N/A
Prediction Method:TAM

 

Reference

[1] PubMed ID:29527968
Disease Name:cervical cancer
Sample:tumor tissues and cell lines of cervical cancer
Dysfunction Pattern:Interaction [NHEJ pathway]
Validated Method:qRT-PCR//RIP//Western blot//RNA pull-down assay//Flow Cytometry//IF staining
Description:We found that LINP1 associates with NHEJ proteins (Ku80 and DNA-PKcs). LINP1 translocates from cytosol to nucleus in response to irradiation. In addition, LINP1 knockdown significantly increases the levels of cleaved caspase3 and PARP, leading to enhanced cell apoptosis after ionizing_radiation (IR). LINP1-knockdown cells showed delayed repairs of DNA double-strand breaks (DSBs) after IR. Finally, LINP1 knockdown increases radiosensitivity of Hela S3 cells.
Author:Wang X,Liu H,Shi L,Yu X,Gu Y,Sun X
Year:2018
Title:LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation.
Causality:Yes