Entry Detail



General Information

Database ID:LDA0007442
Species:Homo sapiens
Confidence Score:0.9612
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:lncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27107777End Site(bp):27134302
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000253552
HGNC ID:HGNC:43745
Entrez Gene:285943
VEGA ID:OTTHUMG00000063274
UCSC ID:uc064cfs.1
ENA:BC035889
RefSeq Accession:NR_122069
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HOXA1
7
27092993
27095996
-
HOXA2
7
27100354
27102811
-
HOXA3
7
27106184
27152581
-
HOXA4
7
27128507
27130799
-
HOXA5
7
27141052
27143668
-
HOXA6
7
27145396
27150603
-
HOXA7
7
27153716
27157936
-
HOXA9
7
27162435
27175180
-
AC004080.3
7
27163535
27180013
-
HOXA10
7
27170591
27180261
-
HOXA11
7
27181510
27185223
-
HOXA13
7
27193503
27200106
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR196B
7
27169480
27169563
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:N/ANeoplasms, Colorectal//Colorectal Neoplasm//Neoplasm, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers

 

Evidence Support

Strong Evidence:MTT assay//qPCR//qRT-PCR
Weak Evidence:N/A
Prediction Method:LDAP

 

Reference

[1] PubMed ID:28112720
Disease Name:colorectal cancer
Sample:colorectal cancer_tissue, cell line
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qRT-PCR//MTT assay
Description:Here, we identified that HOXA-AS2 is significantly upregulated in CRC tissue.
Author:Ding J,Xie M,Lian Y,Zhu Y,Peng P,Wang J,Wang L,Wang K
Year:2017
Title:"Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer."
Causality:Yes

[2] PubMed ID:28112720
Disease Name:colorectal cancer
Sample:N/A
Dysfunction Pattern:Interaction [EZH2/p21]
Validated Method:qPCR
Description:The mechanistic investigations showed that HOXA-AS2 could interact with EZH2 (enhancer of zeste homolog 2), LSD1 (lysine specific demethylase 1) and recruit them to p21 (CDKN1A), KLF2 promoter regions to repress their transcription. Furthermore, the rescue experiments demonstrated that HOXA-AS2 oncogenic function is partly through regulating p21._
Author:Ding J,Xie M,Lian Y,Zhu Y,Peng P,Wang J,Wang L,Wang K
Year:2017
Title:"Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer."
Causality:Yes

[3] PubMed ID:28112720
Disease Name:colorectal cancer
Sample:N/A
Dysfunction Pattern:Interaction [LSD1/KLF2]
Validated Method:qPCR
Description:The mechanistic investigations showed that HOXA-AS2 could interact with EZH2 (enhancer of zeste homolog 2), LSD1 (lysine specific demethylase 1) and recruit them to p21 (CDKN1A), KLF2 promoter regions to repress their transcription. Furthermore, the rescue experiments demonstrated that HOXA-AS2 oncogenic function is partly through regulating p21._
Author:Ding J,Xie M,Lian Y,Zhu Y,Peng P,Wang J,Wang L,Wang K
Year:2017
Title:"Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer."
Causality:Yes