Entry Detail



General Information

Database ID:LDA0007496
Species:Homo sapiens
Confidence Score:0.7226
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:LINC00850
Full Name:long intergenic non-protein coding RNA 850
Category:lncRNA
Species:Homo sapiens
Synonyms:KUCG1
Chromosome:X
Strand:+
Coordinate:
Start Site(bp):149825708End Site(bp):149879799
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000280752
HGNC ID:HGNC:45092
Entrez Gene:101241891
VEGA ID:OTTHUMG00000189730
UCSC ID:uc033ezx.1
ENA:JX283354
RefSeq Accession:NR_109813
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HSFX1
X
149774068
149776867
+
MAGEA9
X
149781930
149787737
+
MAGEA8
X
149881141
149885835
+
CXorf40B
X
149929527
149938811
-
HSFX4
X
149929645
149931287
+
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11723D020388
Disease Name:Duchenne muscular dystrophyMuscular Dystrophy, Duchenne
Category:Disease OntologyMeSH
Type:disease of anatomical entityMusculoskeletal Diseases//Nervous System Diseases//Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Define:A muscular dystrophy that has_material_basis_in X-linked disease that has material basis in mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy.An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Alias:Muscular dystrophy, DuchenneCardiomyopathy, Dilated, X-Linked//Childhood Muscular Dystrophy, Pseudohypertrophic//Childhood Pseudohypertrophic Muscular Dystrophy//Duchenne Muscular Dystrophy//Duchenne-Type Progressive Muscular Dystrophy//Duchenne Type Progressive Muscular Dystrophy//Muscular Dystrophy, Childhood, Pseudohypertrophic//Muscular Dystrophy, Duchenne Type//Muscular Dystrophy, Pseudohypertrophic//Pseudohypertrophic Muscular Dystrophy//Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type//Muscular Dystrophy, Pseudohypertrophic, Childhood//Progressive Muscular Dystrophy, Duchenne Type//Pseudohypertrophic Childhood Muscular Dystrophy//Pseudohypertrophic Muscular Dystrophy, Childhood//Cardiomyopathy, Dilated, 3B//Duchenne and Becker Muscular Dystrophy//Muscular Dystrophy, Duchenne and Becker Types//Duchenne-Becker Muscular Dystrophy//Duchenne Becker Muscular Dystrophy//Muscular Dystrophy, Duchenne-Becker//Becker Muscular Dystrophy//Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type//Muscular Dystrophy, Becker//Muscular Dystrophy, Becker Type//Becker's Muscular Dystrophy//Muscular Dystrophy, Becker's//Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type

 

Evidence Support

Strong Evidence:N/A
Weak Evidence:Array//Genotyping
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:23223008
Disease Name:Duchenne muscular dystrophy
Sample:N/A
Dysfunction Pattern:Mutation
Validated Method:Array//Genotyping
Description:Molecular characterization of an X(p21.2,q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28
Author:Tran TH,Zhang Z,Yagi M,Lee T,Awano H,Nishida A,Okinaga T,Takeshima Y,Matsuo M
Year:2013
Title:Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28.
Causality:No

[2] PubMed ID:23223008
Disease Name:Duchenne muscular dystrophy
Sample:muscle
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Array//Genotyping
Description:We cloned a novel long non-coding gene from a chromosomal break point,It was supposed that this gene may have a role in causing mental retardation in the index case.
Author:Tran TH,Zhang Z,Yagi M,Lee T,Awano H,Nishida A,Okinaga T,Takeshima Y,Matsuo M
Year:2013
Title:Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28.
Causality:No

[3] PubMed ID:24685002
Disease Name:Duchenne muscular dystrophy
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Array//Genotyping
Description:KUCG1 is a 648-bp nuclear lncRNA expressed in a tissue specific manner. Since it is normally expressed in the brain,its deregulation could contribute to the neurological impairment of the patient as already reported for other pathologies.
Author:Neguembor MV,Jothi M,Gabellini D
Year:2014
Title:"Long noncoding RNAs, emerging players in muscle differentiation and disease."
Causality:No