Entry Detail



General Information

Database ID:LDA0007512
Species:Homo sapiens
Confidence Score:0.907
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:SNHG2//NCRNA00030
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863900End Site(bp):173868882
Gene Summary:This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
External Links:
Ensembl ID:ENSG00000234741
HGNC ID:HGNC:16355
Entrez Gene:60674
VEGA ID:OTTHUMG00000037216
UCSC ID:uc057nkb.1
ENA:BC038733
RefSeq Accession:NR_002578
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KLHL20
1
173714941
173786702
+
CENPL
1
173799550
173824720
-
DARS2
1
173824503
173858546
+
ZBTB37
1
173868082
173903549
+
SERPINC1
1
173903804
173917378
-
RC3H1
1
173931214
174022297
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5041D004938
Disease Name:esophageal cancerEsophageal Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A gastrointestinal system cancer that is located_in the esophagus.Tumors or cancer of the ESOPHAGUS.
Alias:Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of abdominal esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of the middle Third of the esophagusEsophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

 

Evidence Support

Strong Evidence:Knockdown//qRT-PCR
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:29386089
Disease Name:esophageal cancer
Sample:EC cells (ECA109, TE-1, TE3 and EC9706)
Dysfunction Pattern:Regulation [miR-301a]
Validated Method:qRT-PCR//Knockdown
Description:The results showed that GAS5 expression was increased in EC cells (ECA109, TE-1, TE3 and EC9706) compared to SHEE cells. Knockdown of GAS5 decreased cell viability, migration, invasion, and induced apoptosis in EC9706 cells. Moreover, miR-301a was directly sponged to GAS5, and miR-301a suppression obviously alleviated the pro-tumor effects of GAS5. Furthermore, miR-301a positively regulated CXCR4 expression, and overexpression of CXCR4 induced apoptosis and abolished the promoting effect of miR-301a inhibition on cell viability, migration and invasion. Besides, miR-301a blocked Wnt/β-catenin and NF-κB signal pathways by regulation of CXCR4.
Author:Li W,Zhao W,Lu Z,Zhang W,Yang X
Year:2018
Title:"Long Noncoding RNA GAS5 Promotes Proliferation, Migration, and Invasion by Regulation of miR-301a in Esophageal Cancer."
Causality:Yes