Entry Detail



General Information

Database ID:LDA0007542
Species:Homo sapiens
Confidence Score:0.9053
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:PCAT1
Full Name:prostate cancer associated transcript 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:PCAT-1//PCA1
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):126847055End Site(bp):127021014
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000253438
HGNC ID:HGNC:43022
Entrez Gene:100750225
VEGA ID:OTTHUMG00000165061
UCSC ID:uc064qdc.1
ENA:HQ605084
RefSeq Accession:NR_045262
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:N/A
miRNA targets:N/A
Display:N/A

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3068D005909
Disease Name:glioblastoma multiformeGlioblastoma
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms
Define:An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derived_from multiple cell types including astrocytes and oligondroctyes.A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Alias:adult glioblastoma multiforme//GBM//GBM (Glioblastoma)//grade IV adult Astrocytic tumor//primary glioblastoma multiforme//spongioblastoma multiformeGlioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:Microarray
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:27306825
Disease Name:Glioblastoma
Sample:glioblastoma cells
Dysfunction Pattern:Expression [low expression]
Validated Method:Microarray//qPCR
Description:PCAT-1 (-2.36), MEG3 (-5.34), HOTAIR (-2.48) lncRNAs showed low expression in glioblastoma compared to the human (parental) brain cancer stem cells, indicating their role as tumour suppressor genes on gliomas.
Author:Balci T,Yilmaz Susluer S,Kayabasi C,Ozmen Yelken B,Biray Avci C,Gunduz C
Year:2016
Title:Analysis of dysregulated long non-coding RNA expressions in glioblastoma cells.
Causality:No