Entry Detail



General Information

Database ID:LDA0007571
Species:Homo sapiens
Confidence Score:0.9026
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:BANCR
Full Name:BRAF-activated non-protein coding RNA
Category:lncRNA
Species:Homo sapiens
Synonyms:LINC00586
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):69296682End Site(bp):69306977
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000278910
HGNC ID:HGNC:43877
Entrez Gene:100885775
VEGA ID:OTTHUMG00000189430
UCSC ID:uc064tpg.1
ENA:AA442164
RefSeq Accession:NR_047671
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL358113.1
9
69035750
69255187
+
TJP2
9
69121264
69255208
+
FAM189A2
9
69324567
69392558
+
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:qRT-PCR//RT-qPCR
Weak Evidence:N/A
Prediction Method:LDAP

 

Reference

[1] PubMed ID:26758762
Disease Name:hepatocellular carcinoma
Sample:N/A
Dysfunction Pattern:Regulation
Validated Method:qRT-PCR
Description:BANCR may contribute to HCC initiation and progression and would be used as not only a novel prognostic marker but also a potential therapeutic target for this disease.
Author:Zhou T,Gao Y
Year:2016
Title:Increased expression of LncRNA BANCR and its prognostic significance in human hepatocellular carcinoma.
Causality:No

[2] PubMed ID:29085476
Disease Name:hepatocellular carcinoma
Sample:HCC cell line Huh7 and a normal liver cell line
Dysfunction Pattern:Expression [overexpression]
Validated Method:RT-qPCR
Description:The results revealed that BANCR was overexpressed in Huh7 cells when compared with normal liver cells. The downregulation of BANCR significantly inhibited the proliferation and colony formation ability, and induced cell cycle arrest and apoptosis of Huh7 cells. The migration and invasion of Huh7 cells were also suppressed in BANCR shRNA-transfected cells. The downregulation of BANCR significantly inhibited the activity of MEK, extracellular signal-regulated kinase and janus kinase signaling pathways.
Author:Li J,Wang J,Zhou W,Zhang S,Le Y,He R
Year:2017
Title:"Downregulation of BRAF-activated non-coding RNA suppresses the proliferation, migration and invasion, and induces apoptosis of hepatocellular carcinoma cells."
Causality:Yes