Entry Detail



General Information

Database ID:LDA0007583
Species:Homo sapiens
Confidence Score:0.9007
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HAGLR
Full Name:HOXD antisense growth-associated long non-coding RNA
Category:lncRNA
Species:Homo sapiens
Synonyms:Mdgt
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):176173195End Site(bp):176188958
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000224189
HGNC ID:HGNC:43755
Entrez Gene:401022
VEGA ID:OTTHUMG00000154172
UCSC ID:N/A
ENA:BC030713
RefSeq Accession:NR_033979
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
EVX2
2
176077472
176083913
-
HOXD13
2
176092891
176095938
+
HOXD12
2
176099730
176101193
+
HOXD11
2
176104216
176109754
+
HOXD10
2
176108790
176119942
+
HOXD9
2
176122720
176124937
+
HOXD8
2
176129694
176132695
+
HOXD3
2
176136612
176173102
+
AC009336.2
2
176151085
176173097
+
HOXD4
2
176151222
176153226
+
HOXD1
2
176188579
176190907
+
MTX2
2
176269395
176338025
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR10B
2
176150303
176150412
+
MIR7704
2
176188843
176188901
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:Microarray
Prediction Method:LDAP

 

Reference

[1] PubMed ID:28724429
Disease Name:hepatocellular carcinoma
Sample:metastatic HCC tissues compared to non-metastatic tissue
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//Microarray
Description:Moreover, we identified that HOXD-AS1 upregulated the Rho GTPase activating protein 11A (ARHGAP11A) by competitively binding to microRNA-19a (miR19a), resulting in induced metastasis._
Author:Lu S,Zhou J,Sun Y,Li N,Miao M,Jiao B,Chen H
Year:2017
Title:The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma.
Causality:Yes