Entry Detail



General Information

Database ID:LDA0007585
Species:Homo sapiens
Confidence Score:0.9026
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HOXA-AS2
Full Name:HOXA cluster antisense RNA 2
Category:lncRNA
Species:Homo sapiens
Synonyms:HOXA3as
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27107777End Site(bp):27134302
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000253552
HGNC ID:HGNC:43745
Entrez Gene:285943
VEGA ID:OTTHUMG00000063274
UCSC ID:uc064cfs.1
ENA:BC035889
RefSeq Accession:NR_122069
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HOXA1
7
27092993
27095996
-
HOXA2
7
27100354
27102811
-
HOXA3
7
27106184
27152581
-
HOXA4
7
27128507
27130799
-
HOXA5
7
27141052
27143668
-
HOXA6
7
27145396
27150603
-
HOXA7
7
27153716
27157936
-
HOXA9
7
27162435
27175180
-
AC004080.3
7
27163535
27180013
-
HOXA10
7
27170591
27180261
-
HOXA11
7
27181510
27185223
-
HOXA13
7
27193503
27200106
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR196B
7
27169480
27169563
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:Knockdown//qRT-PCR
Weak Evidence:N/A
Prediction Method:LDAP

 

Reference

[1] PubMed ID:27855366
Disease Name:hepatocellular carcinoma
Sample:HCC cells, HCC tissues and adjacent normal tissues
Dysfunction Pattern:Expression [high expression]
Validated Method:qRT-PCR//Knockdown
Description:In the present study, we found that HOXA-AS2 expression was increased in HCC tissues and adjacent normal tissues and high HOXA-AS2 expression was associated with bigger tumor size, advanced tumor stage, and shorter survival time.
Author:Wang F,Yang H,Deng Z,Su Y,Fang Q,Yin Z
Year:2016
Title:HOX Antisense lincRNA HOXA-AS2 Promotes Tumorigenesis of Hepatocellular Carcinoma.
Causality:Yes