Entry Detail



General Information

Database ID:LDA0007604
Species:Homo sapiens
Confidence Score:0.9825
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:NPTN-IT1
Full Name:NPTN intronic transcript 1
Category:lncRNA
Species:Homo sapiens
Synonyms:lncRNA-LET
Chromosome:15
Strand:-
Coordinate:
Start Site(bp):73566938End Site(bp):73569543
Gene Summary:N/A
External Links:
Ensembl ID:ENSG00000281183
HGNC ID:HGNC:45091
Entrez Gene:101241892
VEGA ID:OTTHUMG00000189514
UCSC ID:uc032cjb.2
ENA:AK055007
RefSeq Accession:NR_103844
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
REC114
15
73443158
73560014
+
NPTN
15
73560014
73634134
-
miRNA targets:N/A
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:qPCR//RIP//Western blot
Weak Evidence:Bioinformatic analysis
Prediction Method:RWRlncD

 

Reference

[1] PubMed ID:23395002
Disease Name:hepatocellular carcinoma
Sample:HCC tissue, cell line (QSG-7701, LO2, SMMC-7721)
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:qPCR//RIP//Western blot
Description:Aberrant Expression of lncRNA-LET in Tumor Tissue. We found that the lncRNA-LET was generally downregulated in hepatocellular carcinomas,colorectal cancers,and squamous-cell lung carcinomas. hypoxia-induced histone deacetylase 3 repressed lncRNA-LET by reducing the histone acetylation-mediated modulation of the lncRNA-LET promoter region. The downregulation of lncRNA-LET was found to be a key step in the stabilization of nuclear factor 90 protein,which leads to hypoxia-induced cancer cell invasion.
Author:Yang F,Huo XS,Yuan SX,Zhang L,Zhou WP,Wang F,Sun SH
Year:2013
Title:Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.
Causality:Yes

[2] PubMed ID:23395002
Disease Name:hepatocellular carcinoma
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Bioinformatic analysis
Description:In this study,we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas,colorectal cancers,and squamous-cell lung carcinomas.
Author:Yang F,Huo XS,Yuan SX,Zhang L,Zhou WP,Wang F,Sun SH
Year:2013
Title:Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.
Causality:Yes

[3] PubMed ID:24296588
Disease Name:hepatocellular carcinoma
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Bioinformatic analysis
Description:Importantly,another lncRNA-LET (lncRNA low expression in tumor) is found to play a critical role in hypoxia-induced metastasis in HCC
Author:Huang JL,Zheng L,Hu YW,Wang Q
Year:2014
Title:Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma.
Causality:No