Entry Detail



General Information

Database ID:LDA0007608
Species:Homo sapiens
Confidence Score:0.9999
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:NCRNA00079//LINC00079//onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
Gene Summary:This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]
External Links:
Ensembl ID:ENSG00000249859
HGNC ID:HGNC:9709
Entrez Gene:5820
VEGA ID:OTTHUMG00000164871
UCSC ID:uc003ysl.4
ENA:M31519
RefSeq Accession:NR_003367
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MYC
8
127735434
127741434
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR1204
8
127795962
127796028
+
MIR1205
8
127960633
127960695
+
MIR1206
8
128008898
128008956
+
MIR1207
8
128049152
128049238
+
MIR1208
8
128150116
128150188
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:adult Hepatoma//adult primary hepatocellular carcinoma//HCC//HepatomaCarcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Evidence Support

Strong Evidence:CCK-8 assay//ChIP//Dual luciferase reporter gene assay//ISH//qPCR//qRT-PCR//RIP//Transwell invasion assay//Western blot
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:25624916
Disease Name:hepatocellular carcinoma
Sample:HCC tissue, cell line (Huh7, SK-hep1, SMMC-7721, HepG2, Hep3B, PLC/PRF/5, Bel-7402)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR
Description:The relative expression levels of PVT1 were significantly higher in cancerous tissues compared with the corresponding non-cancerous tissues. Furthermore,overexpression of PVT1 was associated with a higher serum a-fetoprotein expression level and a higher recurrence rate. Kaplan-Meier analysis indicated that the patients with high PVT1 expression exhibited poor recurrence-free survival,and multivariate analysis demonstrated that high levels of PVT1 expression are an independent predictor for HCC recurrence.
Author:Ding C,Yang Z,Lv Z,DU C,Xiao H,Peng C,Cheng S,Xie H,Zhou L,Wu J,Zheng S
Year:2015
Title:Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients.
Causality:No

[2] PubMed ID:27495068
Disease Name:hepatocellular carcinoma
Sample:N/A
Dysfunction Pattern:N/A
Validated Method:qPCR
Description:The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis.
Author:Yu J,Han J,Zhang J,Li G,Liu H,Cui X,Xu Y,Li T,Liu J,Wang C
Year:2016
Title:The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis.
Causality:No

[3] PubMed ID:28656879
Disease Name:hepatocellular carcinoma
Sample:cell line (HepG2, Hep3B, Huh-7, HCCLM9, SK-Hep1, SMMC-7721)
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:Dual luciferase reporter gene assay//ISH//qPCR//Western blot
Description:In this study, we investigated the interactions between plasmacytoma variant translocation 1 and miR-186-5p in the progression of hepatocellular carcinoma and explored the functional significance of plasmacytoma variant translocation 1. It was determined that plasmacytoma variant translocation 1 was significantly higher, while miR-186-5p was statistically lower in the hepatocellular carcinoma tissues than that in the adjacent normal tissues.
Author:Lan T,Yan X,Li Z,Xu X,Mao Q,Ma W,Hong Z,Chen X,Yuan Y
Year:2017
Title:Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma.
Causality:Yes

[4] PubMed ID:28656879
Disease Name:hepatocellular carcinoma
Sample:hepatocellular carcinoma tissues and the adjacent normal tissues
Dysfunction Pattern:Expression [high expression]
Validated Method:qPCR
Description:It was determined that plasmacytoma variant translocation 1 was significantly higher, while miR-186-5p was statistically lower in the hepatocellular carcinoma tissues than that in the adjacent normal tissues.
Author:Lan T,Yan X,Li Z,Xu X,Mao Q,Ma W,Hong Z,Chen X,Yuan Y
Year:2017
Title:Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma.
Causality:Yes

[5] PubMed ID:28800314
Disease Name:hepatocellular carcinoma
Sample:HCC tissues and adjacent normal tissues
Dysfunction Pattern:Expression [high expression]
Validated Method:qRT-PCR//CCK-8 assay//Transwell invasion assay//RIP//ChIP
Description:The results showed that PVT1 was increased in HCC tissues and higher PVT1 expression was associated with tumor size, histological differentiation grade and advanced TNM stage. Furthermore, we revealed that PVT1 promoted cell proliferation and invasion in HCC. RIP and ChIP assays demonstrated that PVT1 significantly inhibited miR-214 expression by interacting with enhancer of zeste homolog 2 (EZH2).
Author:Gou X,Zhao X,Wang Z
Year:2017
Title:Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214.
Causality:Yes