Entry Detail



General Information

Database ID:LDA0007645
Species:Homo sapiens
Confidence Score:0.963
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:HOTAIR
Full Name:HOX transcript antisense RNA
Category:lncRNA
Species:Homo sapiens
Synonyms:HOXC-AS4//HOXC11-AS1//NCRNA00072
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):53962308End Site(bp):53974956
Gene Summary:This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with HOXC genes. It represses transcription of HOXD genes on chromosome 2 in trans. This gene is shuttled from chromosome 12 to chromosome 2 by a component of Polycomb Repressive Complex 2 (PRC2). This gene interacts with both PRC2 and lysine specific demethylase 1 (LSD1) complexes through its 5' and 3' domains, respectively, and serves as a scaffold to assemble PRC2 and LSD1 complexes to the HOXD gene cluster. It couples H3K27 methylation and H3K4 demethylation for epigenetic silencing of HOXD genes in multiple tissues. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2013]
External Links:
Ensembl ID:ENSG00000228630
HGNC ID:HGNC:33510
Entrez Gene:100124700
VEGA ID:OTTHUMG00000152934
UCSC ID:uc009zne.5
ENA:DQ926657
RefSeq Accession:NR_003716
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
HOXC13
12
53938765
53946544
+
HOXC12
12
53954834
53958956
+
HOXC11
12
53973126
53977643
+
HOXC10
12
53985065
53990279
+
AC012531.3
12
53985845
54034888
+
HOXC6
12
53990624
54030823
+
HOXC9
12
53994895
54003337
+
HOXC8
12
54009106
54012362
+
HOXC4
12
54016931
54056030
+
HOXC5
12
54032853
54035358
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR196A2
12
53991738
53991847
+
MIR615
12
54033950
54034045
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:263D007680
Disease Name:kidney cancerKidney Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Male Urogenital Diseases//Female Urogenital Diseases and Pregnancy Complications
Define:A urinary system cancer that is located_in the kidney.Tumors or cancers of the KIDNEY.
Alias:malignant neoplasm of kidney except pelvis//malignant tumour of kidney//renal cancerKidney Neoplasm//Neoplasm, Kidney//Renal Neoplasms//Neoplasm, Renal//Neoplasms, Renal//Renal Neoplasm//Neoplasms, Kidney//Cancer of Kidney//Kidney Cancers//Renal Cancer//Cancer, Renal//Cancers, Renal//Renal Cancers//Cancer of the Kidney//Kidney Cancer//Cancer, Kidney//Cancers, Kidney

 

Evidence Support

Strong Evidence:qPCR//RIP//Western blot
Weak Evidence:N/A
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:24616104
Disease Name:kidney cancer
Sample:cell line (86-O, ACHN)
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//RIP//Western blot
Description:We found that HOTAIR expression is inversely correlated to miR-141 expression in renal carcinoma cells. HOTAIR promotes malignancy,including proliferation and invasion,whereas miR-141 suppresses malignancy in human cancer cells. miR-141 binds to HOTAIR in a sequence-specific manner and suppresses HOTAIR expression and functions,including proliferation and invasion.
Author:Chiyomaru T,Fukuhara S,Saini S,Majid S,Deng G,Shahryari V,Chang I,Tanaka Y,Enokida H,Nakagawa M,Dahiya R,Yamamura S
Year:2014
Title:Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells.
Causality:No