Entry Detail



General Information

Database ID:LDA0007661
Species:Homo sapiens
Confidence Score:0.9938
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:PRO1073//MALAT-1//NCRNA00047//HCN//NEAT2//LINC00047//mascRNA
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497762End Site(bp):65506516
Gene Summary:This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
External Links:
Ensembl ID:ENSG00000251562
HGNC ID:HGNC:29665
Entrez Gene:378938
VEGA ID:OTTHUMG00000166322
UCSC ID:uc010roh.5
ENA:AF001540
RefSeq Accession:NR_002819
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
FRMD8
11
65386599
65413525
+
SCYL1
11
65525077
65538704
+
LTBP3
11
65538805
65558930
-
SSSCA1
11
65570430
65573942
+
FAM89B
11
65572349
65574198
+
EHBP1L1
11
65576038
65592650
+
KCNK7
11
65592855
65595996
-
MAP3K11
11
65597755
65615382
-
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR612
11
65444458
65444557
+
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3571D008113
Disease Name:liver cancerLiver Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Digestive System Diseases
Define:A gastrointestinal system cancer that is located_in the liver.Tumors or cancer of the LIVER.
Alias:ca liver - primary//Ca liver - primary (disorder)//hepatic cancer//hepatic neoplasm//malignant hepato-biliary neoplasm//malignant neoplasm of liver//malignant neoplasm of liver (disorder)//malignant neoplasm of liver unspecified (disorder)//malignant neoplasm of liver, not specified as primary or secondary//malignant neoplasm of liver, primary//malignant tumor of liver (disorder)//neoplasm of liver (disorder)//non-resectable primary hepatic malignant neoplasm//primary liver cancer//primary malignant neoplasm of Liver//primary malignant neoplasm of liver//primary malignant neoplasm of liver (disorder)//primary malignant neoplasm of liver NOS (disorder)//Resectable malignant neoplasm of Liver//resectable malignant neoplasm of the liverNeoplasms, Hepatic//Neoplasms, Liver//Liver Neoplasm//Neoplasm, Liver//Hepatic Neoplasms//Hepatic Neoplasm//Neoplasm, Hepatic//Cancer of Liver//Hepatocellular Cancer//Cancers, Hepatocellular//Hepatocellular Cancers//Hepatic Cancer//Cancer, Hepatic//Cancers, Hepatic//Hepatic Cancers//Liver Cancer//Cancer, Liver//Cancers, Liver//Liver Cancers//Cancer of the Liver//Cancer, Hepatocellular

 

Evidence Support

Strong Evidence:Luciferase reporter gene assay//qPCR//RIP//Western blot
Weak Evidence:Microarray
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2//RWRlncD

 

Reference

[1] PubMed ID:21489289
Disease Name:liver cancer
Sample:N/A
Dysfunction Pattern:N/A
Validated Method:Luciferase reporter gene assay//qPCR//RIP//Western blot//Microarray
Description:MALAT1 gene,or metastasis-associated lung adenocarcinoma transcript 1,was first associated with high metastatic potential and poor patient prognosis during a comparative screen of non-small cell lung cancer patients with and without metastatic tumors [135]. This lncRNA is widely expressed in normal human tissues [135,136] and is found to be upregulated in a variety of human cancers of the breast,prostate,colon,liver and uterus.
Author:Gibb EA,Brown CJ,Lam WL
Year:2011
Title:The functional role of long non-coding RNA in human carcinomas.
Causality:No

[2] PubMed ID:22996375
Disease Name:liver cancer
Sample:N/A
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Luciferase reporter gene assay//qPCR//RIP//Western blot//Microarray
Description:Sequesters SR splicing factors to regulate alternative splicing.
Author:Qi P,Du X
Year:2013
Title:"The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine."
Causality:No

[3] PubMed ID:24468535
Disease Name:liver cancer
Sample:liver tissue, cell line (HepG2, Bel-7402, SMMC-7721, HEK-293T)
Dysfunction Pattern:Expression [differentially expressed]
Validated Method:Luciferase reporter gene assay//qPCR//RIP//Western blot//Microarray
Description:Yes-associated protein (YAP),which up-regulated Malat1 expression at both transcriptional and post-transcriptional levels,whereas serine/arginine-rich splicing factor 1 (SRSF1) played an opposing role. SRSF1 inhibited YAP activity by preventing its co-occupation with TCF/β-catenin on the Malat1 promoter. In contrast,overexpression of YAP impaired the nuclear retention of both SRSF1 and itself via an interaction with Angiomotin (AMOT). This effect removed the inhibitory role of SRSF1 on Malat1 in the nucleus.
Author:Wang J,Wang H,Zhang Y,Zhen N,Zhang L,Qiao Y,Weng W,Liu X,Ma L,Xiao W,Yu W,Chu Q,Pan Q,Sun F
Year:2014
Title:"Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer."
Causality:Yes