Entry Detail



General Information

Database ID:LDA0007668
Species:Homo sapiens
Confidence Score:0.958
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:D11S813E//ASM//ASM1//NCRNA00008//LINC00008
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):1995163End Site(bp):2001470
Gene Summary:This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
External Links:
Ensembl ID:ENSG00000130600
HGNC ID:HGNC:4713
Entrez Gene:283120
VEGA ID:OTTHUMG00000012477
UCSC ID:uc057xvv.1
ENA:AF087017
RefSeq Accession:NR_002196
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TNNT3
11
1919562
1938706
+
MRPL23
11
1947278
1984522
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR675
11
1996759
1996831
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910C538231
Disease Name:lung adenocarcinomaAdenocarcinoma of lung
Category:Disease OntologyMeSH
Type:disease of cellular proliferationSupplementary Concept
Define:A non-small cell lung carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:nonsmall cell adenocarcinomaLung adenocarcinoma

 

Evidence Support

Strong Evidence:Knockdown//qPCR
Weak Evidence:Microarray
Prediction Method:LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:25758555
Disease Name:lung adenocarcinoma
Sample:lung tissue
Dysfunction Pattern:Regulation [down-regulated]
Validated Method:qPCR//Microarray
Description:The remaining 10 lncRNAs,showed significantly different expression in the tumor samples. For 9 of these,expression was altered in the same direction as had been detected by microarray analysis (8 lower,and 1 higher,than NT samples, all p < 0.001,).differentially expressed lncRNAs in early stage lung adenocarcinoma and suggest that lncRNAs may be novel candidate biomarkers for the early detection of this disease.
Author:Wang P,Lu S,Mao H,Bai Y,Ma T,Cheng Z,Zhang H,Jin Q,Zhao J,Mao H
Year:2015
Title:Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs.
Causality:No

[2] PubMed ID:27911863
Disease Name:lung adenocarcinoma
Sample:lung adenocarcinoma cells
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:qPCR//Knockdown
Description:In our study, the expression of H19 in cisplatin-resistant A549/DDP cells was unregulated.
Author:Wang Q,Cheng N,Li X,Pan H,Li C,Ren S,Su C,Cai W,Zhao C,Zhang L,Zhou C
Year:2017
Title:Correlation of long non-coding RNA H19 expression with cisplatin-resistance and clinical outcome in lung adenocarcinoma.
Causality:No