Entry Detail



General Information

Database ID:LDA0007691
Species:Homo sapiens
Confidence Score:0.9074
Contents:>> ncRNA Information
>> Regulatory Relationship
>> Disease Information
>> Evidence Support
>> Reference

 

ncRNA Information

ncRNA Symbol:MIAT
Full Name:myocardial infarction associated transcript (non-protein coding)
Category:lncRNA
Species:Homo sapiens
Synonyms:FLJ25967//Rncr2//gomafu//NCRNA00066//LINC00066//lncRNA-MIAT
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):26646428End Site(bp):26676475
Gene Summary:This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
External Links:
Ensembl ID:ENSG00000225783
HGNC ID:HGNC:33425
Entrez Gene:440823
VEGA ID:OTTHUMG00000150985
UCSC ID:uc032qkk.2
ENA:AB263414
RefSeq Accession:NR_003491
UniProtKB:N/A

 

Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TPST2
22
26521983
26596717
-
CRYBB1
22
26599278
26618088
-
CRYBA4
22
26621964
26630672
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MIR548J
22
26555212
26555323
-
Display:

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1324D008175
Disease Name:lung cancerLung Neoplasms
Category:Disease OntologyMeSH
Type:disease of cellular proliferationNeoplasms//Respiratory Tract Diseases
Define:A respiratory system cancer that is located_in the lung.Tumors or cancer of the LUNG.
Alias:N/APulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

 

Evidence Support

Strong Evidence:Knockdown
Weak Evidence:Univariate and Multivariate Cox regression analyses
Prediction Method:LDAP//LRLSLDA-LNCSIM1//LRLSLDA-LNCSIM2

 

Reference

[1] PubMed ID:29487526
Disease Name:lung cancer
Sample:lung cancer tissues and adjacent tissues
Dysfunction Pattern:Regulation [up-regulated]
Validated Method:Knockdown//Univariate and Multivariate Cox regression analyses
Description:Here, we showed that the expression of MIAT in lung cancer tissues was upregulated compared with adjacent tissues. LncRNA MIAT expression was associated with tumor size, lymph node metastasis, distant metastasis and TNM stage. Univariate analysis and multivariate analysis revealed that the lncRNA MIAT to be an independent factor for predicating the prognosis of lung cancer patients. Low lncRNA MIAT have longer overall survival time and progression-free survival time than patients with high lncRNA MIAT expression. Moreover, the knockdown of MIAT significantly sensitized PC9 and gefitinib-resistant PC9 cells to gefitinib_in vitro_and_in vivo, and increased the expression of miR-34a and inactivated PI3K/Akt signaling. MIAT interacted with miR-34a and epigenetically controlled the miR-34a expression by hyper-methylating its promotor.
Author:Fu Y,Li C,Luo Y,Li L,Liu J,Gui R
Year:2018
Title:Silencing of Long Non-coding RNA MIAT Sensitizes Lung Cancer Cells to Gefitinib by Epigenetically Regulating miR-34a.
Causality:Yes