Entry Detail

General Information

Database ID: LDA0005835
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OIP5-AS1
Full Name:OIP5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:cyrano|linc-OIP5
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):41282697End Site(bp):41313338
External Links:
Ensembl ID:ENSG00000247556
Ensembl Transcript ID:N/A
Entrez Gene:729082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:68   
More Information
Causal Disease Number:62
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Lung Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077216
Disease Name:Carcinoma, Ovarian Epithelial
Category:MeSH
Type:Neoplasms
Define:A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
Alias:Carcinoma, Ovarian Epithelial//Epithelial Carcinoma, Ovarian//Ovarian Epithelial Carcinomas//Epithelial Ovarian Cancer//Ovarian Epithelial Cancer//Cancer, Ovarian Epithelial//Epithelial Cancer, Ovarian//Ovarian Epithelial Cancers//Ovarian Cancer, Epithelial//Cancer, Epithelial Ovarian//Epithelial Ovarian Cancers//Ovarian Epithelial Carcinoma//Epithelial Ovarian Carcinoma//Carcinoma, Epithelial Ovarian//Epithelial Ovarian Carcinomas//Ovarian Carcinoma, Epithelial

 

Disease Association Statistics

Total Associated ncRNA Number:102   
More Information
Causal ncRNA Number:80
Network:
Top Causal ncRNAs:
HIF1A-AS2  (Score: 0.985791)
HIF1A-AS2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
hsa_circ_0072995  (Score: 0.731059)
circATP2B4  (Score: 0.731059)
HOXB-AS3  (Score: 0.731059)
circRHOBTB3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32801903
Disease Name:Carcinoma, Ovarian Epithelial
Sample:EOC tissues
Dysfunction Pattern:regulation[OIP5-AS1/miR-137/ZNF217 Axis]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay
Description: We found that OIP5-AS1 was significantly overexpressed in EOC. OIP5-AS1 regulated ovarian cancer progression via modulating miR-137/ZNF217 signaling, suggesting that targeting OIP5-AS1 could be conducive to EOC clinical treatment.
Causality:Yes
Causal Description: Knockdown of OIP5-AS1 inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process, yet facilitated apoptosis in vitro.
Clinical-realted Application: