Welcome to LncRNADisease v3.0


Long non-coding RNAs (lncRNAs) are an important category of non-coding RNAs (ncRNAs) which range from 200 nucleotides to multiple kilobases in length, with little or no protein-coding capacity. Circular RNAs (circRNAs) are widely expressed in diverse eukaryotic species and are characterized by covalently closed RNA loops through backsplicing events. Increasing evidence has highlighted the critical roles of lncRNAs and circRNAs in plenty of diseases development and progression. Here, we have updated the LncRNADisease database to version 3.0 by integrating comprehensive experimentally supported and predicted ncRNA-disease associations curated from manual literatures and other resources. The new developments in LncRNADisease v3.0 include (I) integrating over 2-fold experimentally supported ncRNA-disease associations enhancement compare to the previous version; (II) integrating circRNA-disease associations; (II) significantly increasing the causative associations between ncRNAs and diseases; (III) mapping disease name to the Disease Ontology and Medical Subject Headings (MeSH).



Database Summary




Citation

Chen et al., LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 2013 Jan 1;41(D1):D983-6.

Bao et al., LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. Nucleic Acids Res. 2019 Jan 8;47(D1):D1034-D1037.

Lin et al., LncRNADisease v3.0: an updated database of long non-coding RNA-associated diseases. Nucleic Acids Res. 2024 Jan 5;52(D1):D1365-D1369. doi: 10.1093/nar/gkad828.