Entry Detail

General Information

Database ID: LDA0000029
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA10
Full Name:homeobox A10
Category:LncRNA
Species:Homo sapiens
Synonyms:HOX1|HOX1.8|HOX1H|PL
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):27170605End Site(bp):27179861
External Links:
Ensembl ID:ENSG00000253293
Ensembl Transcript ID:N/A
Entrez Gene:3206.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5520D000077195
Disease Name:head and neck squamous cell carcinomaSquamous Cell Carcinoma of Head and Neck
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
Alias:carcinoma of the head and neck//squamous cell carcinoma of the head and neck//squamous cell carcinomas of head and neckSquamous Cell Carcinoma of Head and Neck//Head And Neck Squamous Cell Carcinomas//Squamous Cell Carcinoma, Head And Neck//Squamous Cell Carcinoma of the Head and Neck//Head and Neck Squamous Cell Carcinoma//HNSCC//Carcinoma, Squamous Cell of Head and Neck//Squamous Cell Carcinoma of the Larynx//Laryngeal Squamous Cell Carcinoma//Squamous Cell Carcinoma of Larynx//Squamous Cell Carcinoma of the Nasal Cavity//Oral Tongue Squamous Cell Carcinoma//Hypopharyngeal Squamous Cell Carcinoma//Oral Squamous Cell Carcinoma//Oral Cavity Squamous Cell Carcinoma//Oral Squamous Cell Carcinomas//Squamous Cell Carcinoma of the Mouth//Oropharyngeal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:632   
More Information
Causal ncRNA Number:464
Network:
Top Causal ncRNAs:
XIST  (Score: 1)
CYTOR  (Score: 1)
hsa_circ_0001971  (Score: 1)
MALAT1  (Score: 1)
GAS5  (Score: 1)
HOXA11-AS  (Score: 1)
NORAD  (Score: 1)
MEG3  (Score: 1)
NEAT1  (Score: 1)
CYTOR  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:33831733
Disease Name:Squamous Cell Carcinoma of Head and Neck
Sample:OSCC stem cells and tumor tissues
Dysfunction Pattern:Interaction(microRNA-29a/MCL-1/phosphatidyl inositol 3-kinase/protein kinase B axis)
Validated Method:CCK8//qRT-PCR
Description:HOXA10-AS and MCL-1 were highly expressed while miR-29a was poorly expressed in the collected tumor tissues and the extracted OSCC stem cells. In addition, HOXA-10-AS and MCL-1 were found to activate the phosphatidyl inositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway.
Causality:Yes
Causal Description:Silencing of HOXA10-AS suppressed proliferation and tumor sphere formation ability of stem cells, and it reduced growth and metastasis of tumors in animals.
Clinical-realted Application:. High expression of HOXA10-AS and MCL-1, while poor expression of miR-29a was relevant to poor prognosis in patients.