Entry Detail

General Information

Database ID: LDA0000046
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIRM1
Full Name:HOXA transcript antisense RNA, myeloid-specific 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS1|HOXA1-AS1|NCRNA00179
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27096094End Site(bp):27100258
External Links:
Ensembl ID:ENSG00000233429
Ensembl Transcript ID:N/A
Entrez Gene:100506311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Thyroid Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077273
Disease Name:Thyroid Cancer, Papillary
Category:MeSH
Type:Neoplasms
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

 

Disease Association Statistics

Total Associated ncRNA Number:340   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
BICDL3P  (Score: 0.999358)
BICDL3P  (Score: 0.999358)
hsa_circ_0000644  (Score: 0.985791)
circRAPGEF5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32269214
Disease Name:Thyroid Cancer, Papillary
Sample:PTC tissues
Dysfunction Pattern:regulation[HOTAIRM1/miR-107/TDG axis]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:In this study, we used quantitative reverse transcription PCR (qRT-PCR) to show that HOTAIRM1 was significantly downregulated in PTC tissues and low HOTAIRM1 expression levels were associated with lymph node metastasis and advanced TNM stage. In conclusion, we validated HOTAIRM1 as a novel tumor-suppressor lncRNA in PTC and proposed that the HOTAIRM1/miR-107/TDG axis may serve as a therapeutic target for PTC.
Causality:Yes
Causal Description:Overexpression of HOTAIRM1 was found to inhibit PTC cell proliferation, invasion, and migration in vitro.
Clinical-realted Application:In this study, we used quantitative reverse transcription PCR (qRT-PCR) to show that HOTAIRM1 was significantly downregulated in PTC tissues and low HOTAIRM1 expression levels were associated with lymph node metastasis and advanced TNM stage.