Entry Detail

General Information

Database ID: LDA0000049
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIRM1
Full Name:HOXA transcript antisense RNA, myeloid-specific 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS1|HOXA1-AS1|NCRNA00179
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27096094End Site(bp):27100258
External Links:
Ensembl ID:ENSG00000233429
Ensembl Transcript ID:N/A
Entrez Gene:100506311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Thyroid Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080522D065646
Disease Name:thyroid gland anaplastic carcinomaThyroid Carcinoma, Anaplastic
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thyroid gland carcinoma that is composed of undifferentiated cells.An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
Alias:anaplastic thyroid carcinomaThyroid Carcinoma, Anaplastic//Anaplastic Thyroid Carcinoma//Anaplastic Thyroid Carcinomas//Carcinoma, Anaplastic Thyroid//Carcinomas, Anaplastic Thyroid//Thyroid Carcinomas, Anaplastic//Thyroid Cancer, Anaplastic//Anaplastic Thyroid Cancer//Anaplastic Thyroid Cancers//Cancer, Anaplastic Thyroid//Cancers, Anaplastic Thyroid//Thyroid Cancers, Anaplastic

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.985791)
UCA1  (Score: 0.985791)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP-AS1  (Score: 0.731059)
MANCR  (Score: 0.731059)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//qPCR//Luciferase Report Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32951513
Disease Name:Thyroid Carcinoma, Anaplastic
Sample:ATC of papillary thyroid cancer
Dysfunction Pattern:Interaction(miR-144 / MET/AKT signalling)
Validated Method:In Vivo Experiment//Western Blot//qPCR//Luciferase Report Assay//Invasion Assay
Description:In this study, we identified a long noncoding RNA (lncRNA) HOTAIRM1, whose encoding gene was amplified and expression was upregulated in ATC compared with papillary thyroid cancer and normal thyroid. HOTAIRM1 was found to bind ILF3, repress the binding between ILF3 and precursor miR-144 (pre-miR-144), block the effects of ILF3 on stabilizing pre-miR-144, and therefore downregulate pre-miR-144. Intriguingly, HOTAIRM1 was also found to directly bind primary miR-144 (pri-miR-144), repress the binding between pri-miR-144 and DROSHA, block the processing of pri-miR-144 by DROSHA, and therefore upregulate pri-miR-144 and downregulate pre-miR-144.
Causality:Yes
Causal Description:Functional assays revealed that HOTAIRM1 promoted proliferation, inhibited apoptosis, and promoted migration and invasion of ATC cells in vitro, and promoted ATC tumour growth and metastasis in vivo.
Clinical-realted Application:Increased genomic copy number and expression of HOTAIRM1 were both correlated with poor survival of ATC patients.