Entry Detail

General Information

Database ID: LDA0000054
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA11-AS
Full Name:HOXA11 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27185408End Site(bp):27189293
External Links:
Ensembl ID:ENSG00000240990
Ensembl Transcript ID:N/A
Entrez Gene:221883.0
NONCODE ID:N/A
RefSeq Accession:NR_002795.2

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Keloid  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4159D012878
Disease Name:skin cancerSkin Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.Tumors or cancer of the SKIN.
Alias:CA - skin cancer//malignant neoplasm of skin//melanoma and Non-melanoma skin cancerSkin Neoplasms//Neoplasms, Skin//Neoplasm, Skin//Skin Neoplasm//Cancer of Skin//Skin Cancers//Cancer of the Skin//Skin Cancer//Cancer, Skin//Cancers, Skin

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
circSEC24A  (Score: 0.731059)
circLARP1B  (Score: 0.731059)
PRECSIT  (Score: 0.731059)
SCARNA2  (Score: 0.731059)
H19  (Score: 0.731059)
EZR‑AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Flow Cytometry//Transfection//Transwell Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:33442511
Disease Name:Skin Neoplasms
Sample:human skin cancer tissues and cell lines
Dysfunction Pattern:Interaction(PI3K/AKT/mTOR signaling pathway)
Validated Method:Flow Cytometry//Transfection//Western Blot//Transwell Assay
Description:The results showed significant (P < 0.05) upregulation of lncRNA HOXA11-AS transcript levels in human skin cancer tissues and cell lines. Flow cytometry showed that HOXA11-AS knockdown triggered arrest of the A375 and HMCB cells at G2/M check point of cell cycle by inhibiting the expression of cyclin B1. Additionally, western blot analysis showed that HOXA11-AS knockdown resulted in the deactivation of PI3K/AKT/mTOR signaling pathway.
Causality:Yes
Causal Description:knockdown of HOXA11-AS significantly (P < 0.05) inhibited the proliferation and colony formation of A375 and HMCB skin cancer cells.
Clinical-realted Application: