Entry Detail

General Information

Database ID: LDA0000055
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXA11-AS
Full Name:HOXA11 antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27185408End Site(bp):27189293
External Links:
Ensembl ID:ENSG00000240990
Ensembl Transcript ID:N/A
Entrez Gene:221883.0
NONCODE ID:N/A
RefSeq Accession:NR_002795.2

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Glioma  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Keloid  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007627
Disease Name:Keloid
Category:MeSH
Type:Tissues
Define:A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
Alias:Keloid//Keloids

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
GNAS-AS1  (Score: 0.731059)
CACNA1G-AS1  (Score: 0.731059)
hsa_circ_0043688  (Score: 0.731059)
circNRIP1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
GNAS-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qPCR//Migration Assay//CCK8//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35987744
Disease Name:Keloid
Sample:tissues and fibroblasts of keloid
Dysfunction Pattern:Interaction(miR-182-5p on ZNF217)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Wound Healing Assay//qPCR//CCK8//Flow Cytometry//RIP//Luciferase Report Assay//Bioinformatics Analysis
Description:HOXA11-AS was highly expressed in tissues and fibroblasts of keloid. Deficiency of HOXA11-AS blocked the proliferation and migration of keloid fibroblasts and induced fibroblast apoptosis. HOXA11-AS directly combined to miR-182-5p whose downregulation reversed the effects of HOXA11-AS knockdown. ZNF217 was a target of miR-182-5p, and HOXA11-AS indirectly promoted ZNF217 expression by binding to miR-182-5p. MiR-182-5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects. HOXA11-AS knockdown also hindered the growth of keloid in mouse models.
Causality:Yes
Causal Description:Deficiency of HOXA11-AS blocked the proliferation and migration of keloid fibroblasts and induced fibroblast apoptosis. HOXA11-AS directly combined to miR-182-5p whose downregulation reversed the effects of HOXA11-AS knockdown. ZNF217 was a target of miR-182-5p, and HOXA11-AS indirectly promoted ZNF217 expression by binding to miR-182-5p. MiR-182-5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects. HOXA11-AS knockdown also hindered the growth of keloid in mouse models.
Clinical-realted Application:

[2] PubMed ID:33261854
Disease Name:Keloid
Sample:keloid tissues and keloid fibroblasts
Dysfunction Pattern:Interaction(miR-205-5p-FOXM1 Pathway)
Validated Method:Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//Invasion Assay
Description: HOXA11-AS and FOXM1 were significantly upregulated in keloid tissues and keloid fibroblasts, while miR-205-5p was downregulated. MiR-205-5p was targeted by HOXA11-AS, and its inhibition overturned the effects of HOXA11-AS knockdown. Moreover, FOXM1 was a target of miR-205-5p, and HOXA11-AS regulated the expression of FOXM1 by adsorbing miR-205-5p.
Causality:Yes
Causal Description:HOXA11-AS knockdown or miR-205-5p enrichment inhibited proliferation, migration, invasion, ECM accumulation, and glycolysis but accelerated apoptosis of keloid fibroblasts.
Clinical-realted Application: